F0101 | Depolarization

Compound Dose Time Species Model Method Action Result Positive criterion Reference
Paraquat increase Positive 67
Cyclosporin A 1 μmol/L 3 minutes rat liver mitochondria Assessment of Mitochondrial Membrane Potential; coincubated with diclofenac decrease Positive p < 0.05 6
DPPD 1 μmol/L 3 minutes rat liver mitochondria Assessment of Mitochondrial Membrane Potential; coincubated with diclofenac decrease Positive p < 0.05 6
Clozapine Increase Positive 307
Bupivacaine decrease Positive 61
Lidocaine Positive 197