F0502 | Liver-specific oxidative stress


Oxidative stress >> Liver-specific oxidative stress

Compound Dose Time Species Model Method Action Result Positive criterion Reference
Acetaminophen 300 mg/kg 3 hours mice; C57Bl/6 in vivo ALT activity measurement increase Positive p < 0.05 1
Acetaminophen 300 mg/kg 6 hours mice; C57Bl/6 in vivo ALT activity measurement increase Positive p < 0.05 1
Acetaminophen 300 mg/kg 24 hours mice; C57Bl/6 in vivo ALT activity measurement increase Positive p < 0.05 1
Acetaminophen 1.5 g/kg 24 hours rat; Fischer (F344) in vivo ALT activity measurement increase Positive p < 0.05 1