F050401 | H2O2 production
| Compound | Dose | Time | Species | Model | Method | Action | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Manganese | 15 mg/l in drinking water | Swiss Albino mice | increase | Positive | 242 | ||||
| Methylmercury | 15 mg/l in drinking water | Swiss albino mice | Positive | 242 | |||||
| Gentamicin | 5mM | 10min | rat | isolated rat liver (and kidney) mitochondria | Mitochondrial ROS production can be measured using Amplex Red, a dye that fluoresces dependent on hydrogen peroxide (H2O2) levels. | reduce | Positive | 316 | |
| glyceraldehyde 3-phosphate | 2.5mM | decrease | Positive | 162 | |||||
| dihydroxyacetone phosphate | decrease | Positive | 162 | ||||||