T251 Source: Uniprot
enzymeDihydroorotate dehydrogenase
(DHOdehase)
Oxidoreductase
| Full Name | Dihydroorotate dehydrogenase |
|---|---|
| Protein Names | Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase) |
| Subcellular Location | Mitochondrion inner membrane Single-pass membrane protein |
| EC numbers | 1.3.5.2 |
| Uniprot Accession | Q02127 |
| Uniprot Name | PYRD_HUMAN |
| Gene symbol | DHODH |
| Gene Name | Dihydroorotate dehydrogenase (quinone) |
| Ensembl | ENSG00000102967 |
| Compound | Dose | Time | Species | Model | Method | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Teriflunomide | Positive | 295 | ||||||
| Leflunomide | 50 μM | 48 hr | HeLa cells, C2C12 muscle cells, MEF cells | Mfn2 and Mfn1 mRNA levels; MFN2, MFN1, and porin protein levels; images of mitochondrial morphology ; | Positive | 295 | ||
| brequinar sodium | 1 μM | 48hr | C2C12 cells | Positive | 295 | |||