Regulator

Full Name	Apoptosis regulator Bcl-2
Protein Names	Apoptosis regulator Bcl-2
Subcellular Location	Endoplasmic reticulum membrane Mitochondrion outer membrane Nucleus membrane Single-pass membrane protein
Uniprot Accession	P10415
Uniprot Name	BCL2_HUMAN
Gene symbol	BCL2
Gene Name	BCL2, apoptosis regulator
Ensembl	ENSG00000171791

Related Drugs/Compounds

Compound	Dose	Time	Species	Model	Method	Result	Positive criterion	Reference
Clotrimazole	150 mg/kg/day	6 days a week for two weeks	human	CAL27(xenograft tumors)/mouse	Immunohistochemistry	Positive	1.5-fold decrease	5
Clotrimazole	40 µM	12 hours	human	CAL27	western blot	Positive	2.1875-fold decrease	5
Clotrimazole	40 µM	12 hours	human	UM1	western blot	Positive	1.35-fold decrease	5
Clotrimazole	40 µM	24 hours	human	CAL27	western blot	Positive	3.1818-fold decrease	5
Clotrimazole	40 µM	24 hours	human	UM1	western blot	Positive	1.5-fold decrease	5
Clotrimazole	40 µM	48 hours	human	CAL27	western blot	Positive	3.3333-fold decrease	5
Clotrimazole	40 µM	48 hours	human	UM1	western blot	Positive	1.5882-fold decrease	5
Bafilomycin A1						Positive		200

Associated Functions

F0701. Apoptosis