T403 Source: Uniprot

proteinApoptosis regulator Bcl-2
Regulator
Full Name Apoptosis regulator Bcl-2
Protein Names Apoptosis regulator Bcl-2
Subcellular Location Endoplasmic reticulum membrane Mitochondrion outer membrane Nucleus membrane Single-pass membrane protein
Uniprot Accession P10415
Uniprot Name BCL2_HUMAN
Gene symbol BCL2
Gene Name BCL2, apoptosis regulator
Ensembl ENSG00000171791

Compound Dose Time Species Model Method Result Positive criterion Reference
Clotrimazole 150 mg/kg/day 6 days a week for two weeks human CAL27(xenograft tumors)/mouse Immunohistochemistry Positive 1.5-fold decrease 5
Clotrimazole 40 µM 12 hours human CAL27 western blot Positive 2.1875-fold decrease 5
Clotrimazole 40 µM 12 hours human UM1 western blot Positive 1.35-fold decrease 5
Clotrimazole 40 µM 24 hours human CAL27 western blot Positive 3.1818-fold decrease 5
Clotrimazole 40 µM 24 hours human UM1 western blot Positive 1.5-fold decrease 5
Clotrimazole 40 µM 48 hours human CAL27 western blot Positive 3.3333-fold decrease 5
Clotrimazole 40 µM 48 hours human UM1 western blot Positive 1.5882-fold decrease 5
Bafilomycin A1 Positive 200