T409 Source: Uniprot
enzymeCaspase-3
(CASP-3)
Thiol protease
Protease
Hydrolase
| Full Name | Caspase-3 |
|---|---|
| Protein Names | Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] |
| Subcellular Location | Cytoplasm |
| EC numbers | 3.4.22.56 |
| Uniprot Accession | P42574 |
| Uniprot Name | CASP3_HUMAN |
| Gene symbol | CASP3 |
| Gene Name | Caspase 3 |
| Ensembl | ENSG00000164305 |
| Compound | Dose | Time | Species | Model | Method | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Troglitazone | 100 µM | 24hr | HepG2 cells | Apo-One homogeneous caspase 3 assay kit | Positive | 330 | ||
| Niclosamide | Positive | 294 | ||||||
| sertraline | Positive | 307 | ||||||
| Fluoxetine | Positive | 307 | ||||||