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T489 Source: Uniprot

enzymeMitofusin-1 (MFN1)
Hydrolase
Full Name Mitofusin-1
Protein Names Mitofusin-1
Uniprot Accession Q8IWA4
Uniprot Name MFN1_HUMAN
Gene symbol MFN1

Compound Dose Time Species Model Method Result Positive criterion Reference
Tetramethylpyrazine 48hr Mfn1−/− MEFs stably expressing an Mfn1 promoter reporter construct Relative luciferase activity was determined in Mfn1−/− MEFs carrying the Mfn1 promoter reporter Positive 276
U74389G 48hr Mfn1−/− MEFs stably expressing an Mfn1 promoter reporter construct Relative luciferase activity was determined in Mfn1−/− MEFs carrying the Mfn1 promoter reporter Positive 276
Tanshinone IIA 48hr Mfn1−/− MEFs stably expressing an Mfn1 promoter reporter construct Relative luciferase activity was determined in Mfn1−/− MEFs carrying the Mfn1 promoter reporter Positive 276
Terbinafine 48hr Mfn1−/− MEFs stably expressing an Mfn1 promoter reporter construct Relative luciferase activity was determined in Mfn1−/− MEFs carrying the Mfn1 promoter reporter Positive 276
Chlorpyrifos 30 μM Human Human induced pluripotent stem cells (iPSCs) Positive 242
piceatannol 48hr Mfn1−/− MEFs stably expressing an Mfn1 promoter reporter construct Relative luciferase activity was determined in Mfn1−/− MEFs carrying the Mfn1 promoter reporter Positive 276

F030804. fission
F030803. fusion