Drug
D0481 | procarbazine
L
L01XB01 Procarbazine
[L01XB] Methylhydrazines
[L01X] OTHER ANTINEOPLASTIC AGENTS
[L01] ANTINEOPLASTIC AGENTS
[L] Antineoplastic and immunomodulating agents
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| UNCOUPLING | rat | isolated liver mitochondria | measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay | increase | 53 | |||
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LD50 | unreported | 350mg/kg (350mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 363, 1970. | |
| rat | LD50 | intraperitoneal | > 400mg/kg (400mg/kg) | Advances in Teratology. Vol. 3, Pg. 181, 1968. | |
| mouse | LD50 | intraperitoneal | 614mg/kg (614mg/kg) | JNCI, Journal of the National Cancer Institute. Vol. 62, Pg. 911, 1979. | |
| 0319AC | 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine | 2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine |
| 35S93Y190K | 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide | 4-[(2-methylhydrazin-1-yl)methyl]-N-(propan-2-yl)benzamide |
| 4-[(2-methylhydrazinyl)methyl]-N-(propan-2-yl)benzamide | 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide | 671-16-9 |
| 671P169 | AC-4547 | AK116452 |
| AKOS015891211 | API0006342 | AX8149098 |
| BCP12198 | BIDD:GT0183 | BPBio1_001369 |
| BRN 0958270 | BSPBio_001244 | Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)- |
| Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)- (9CI); | Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]- | C-23731 |
| C07402 | C12H19N3O | CAS-366-70-1 |
| CAS-671-16-9 | CB 400-497 | CC-33928 |
| CCG-213031 | CCRIS 2389 | CHEBI:71417 |
| CHEMBL1321 | CPTBDICYNRMXFX-UHFFFAOYSA-N | D08423 |
| DB-082065 | DB01168 | DSSTox_CID_1189 |
| DSSTox_GSID_21189 | DSSTox_RID_75999 | DTXSID4021189 |
| EINECS 211-582-2 | FT-0737820 | GTPL7278 |
| HMS2090J09 | HSDB 3250 | IBZ |
| Ibenzmethyzin | Ibenzmethyzine | LS-7671 |
| MBH (Salt/Mix) | MCULE-9065058360 | MIH |
| Matulane (Salt/Mix) | N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide | N-(1-Methylethyl)-4-[(2-methylhydrazino)methyl]benzamide |
| N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine | N-Isopropyl-.alpha.-(2-methylhydrazino)-p-toluamide | N-Isopropyl-4-((2-methylhydrazinyl)methyl)benzamide |
| N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide | N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide # | N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide |
| N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide | NCGC00016438-01 | NCGC00016438-02 |
| NCGC00016438-05 | NCGC00255280-01 | NCI60_041703 |
| NCIOpen2_004074 | NSC-759626 | NSC759626 |
| Nathulane (Salt/Mix) | Natulan | Natunalar (Salt/Mix) |
| PCX | Pharmakon1600-01502326 | Prestwick0_001112 |
| Prestwick1_001112 | Prestwick2_001112 | Prestwick3_001112 |
| Procarbazin | Procarbazin [German] | Procarbazina |
| Procarbazina [INN-Spanish] | Procarbazine (INN) | Procarbazine Monohydrochloride |
| Procarbazine [INN:BAN] | Procarbazinum | Procarbazinum [INN-Latin] |
| Q418656 | RO-4-6467 | RO-4-6467 FREE BASE |
| Ro 4-6467 | Ro 4-6467/1 | Ro-4-6467/1 |
| SCHEMBL4656 | SPBio_003112 | SR-01000763375 |
| SR-01000763375-3 | SRI-10847 | SRI-10847-09 |
| SRI-10847-10 | SRI-10847_11 | SRI-10847_13 |
| STL483417 | Tox21_301738 | UNII-35S93Y190K |
| ZINC19166988 | p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide | p-(N'-Methylhydrazinomethyl)-N-isopropylbenzamide |
| p-Toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)- | p-Toluamide, N-isopropyl-alpha-(2-methylhydrazino)- | procarbazine |