Compound	Dose	Time	Species	Model	Method	Action	Result	Positive criterion	Reference
2,4-dinitrophenol						increase	Positive		24
CCCP						increase	Positive		27
Amiodarone	100 μmol/L		rat; Sprague–Dawley	hepatocytes	Measurement of oxygen uptake	affect	Positive	p < 0.01	4
Salicylic acid						increase	Positive		31
benzarone	50 μmol/L		rat; Sprague–Dawley	hepatocytes	Measurement of oxygen uptake	affect	Positive	p < 0.01	4
benzarone	80 μmol/L		rat; Sprague–Dawley	hepatocytes	Measurement of oxygen uptake	affect	Positive	p < 0.01	4
benzarone	100 μmol/L		rat; Sprague–Dawley	hepatocytes	Measurement of oxygen uptake	affect	Positive	p < 0.01	4
benzbromarone						increase	Positive		35
benzbromarone	10 μmol/L		rat; Sprague–Dawley	hepatocytes	Measurement of oxygen uptake	affect	Positive	p < 0.01	4
Entacapone						increase	Positive		35
benzbromarone	20 μmol/L		rat; Sprague–Dawley	hepatocytes	Measurement of oxygen uptake	affect	Positive	p < 0.01	4
benzbromarone	50 μmol/L		rat; Sprague–Dawley	hepatocytes	Measurement of oxygen uptake	affect	Positive	p < 0.01	4
benzbromarone	80 μmol/L		rat; Sprague–Dawley	hepatocytes	Measurement of oxygen uptake	affect	Positive	p < 0.01	4
benzbromarone	100 μmol/L		rat; Sprague–Dawley	hepatocytes	Measurement of oxygen uptake	affect	Positive	p < 0.01	4
Nimesulide						increase	Positive		35
Primaquine						increase	Positive		35
Tolcapone						increase	Positive		35
2,4-dinitrophenol						increase	Positive		35
CCCP						increase	Positive		35
FCCP						increase	Positive		35
Papaverine						increase	Positive		35
alpidem						increase	Positive		36
Diclofenac						increase	Positive		39
Diflunisal						increase	Positive		40
Hexachlorophene						increase	Positive		42
Ketoconazole						increase	Positive		36
lovastatin						increase	Positive		36
Nimesulide						increase	Positive		36
Nitrofurantoin						increase	Positive		36
Rosiglitazone						increase	Positive		7
sitaxsentan						increase	Positive		44
Tamoxifen						increase	Positive		46
erlotinib						increase	Positive		36
CCCP	1e-6M		bovine	frozen beef heart mitochondria	Succinate oxidation was measured manometrically in a Warburg apparatus. Oxidation of B-hydroxy- butyrate was determined by colorlmetric assay of acetoacetate (4). Glucose-6-phosphate formed was assayed spectrophotometrically by the reduction of TPN in the presence of glucose-6-phosphate dehydrogenase.	increase	Positive		220
imipramine						increase	Positive		36
Menadione						increase	Positive		47
2,4-dinitrophenol	1.6e-6M			Mitochondria from several sources: mouse liver, rat liver, beef heart,	delta 02, delta G-6-P, P/O (with Succinate)	increase	Positive		221
2,4-dinitrophenol	0.002M			phosphorylating particles from Alcaligenes faecalis contain a coupling enzyme or enzymes bound to the DPNH oxidase particles by magnesium ion and a specific oligoribonucleotide		increase	Positive		222
pentamidine						increase	Positive		51
Indomethacin			rat	heart			Positive		197
Diclofenac			rat	heart			Positive		197
para-nonylphenol			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	increase	Positive		53
Nimesulide						affect	Positive		197
Nimesulide							Positive		197
Meloxicam							Positive		197
Indomethacin							Positive		197
ezlopitant			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	increase	Positive		53
procarbazine			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	increase	Positive		53
Indomethacin							Positive		197
rifabutin			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	increase	Positive		53
ritolukast			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	increase	Positive		53
Trifluoperazine			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	increase	Positive		53
Diclofenac							Positive		197
crizotinib			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	increase	Positive		53
tenidap			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	increase	Positive		53
benztropine mesylate			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	increase	Positive		53
clemastine			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	increase	Positive		53
darifenacin			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	increase	Positive		53
protriptyline			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	increase	Positive		53
tolterodine			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	increase	Positive		53
Etodolac				isolated mitochondria		increase	Positive		56
Indomethacin			rat	isolated liver mitochondria		increase	Positive		65
ochratoxin a			rat	isolated liver mitochondria		increase	Positive		66
Paraquat						increase	Positive		67
Cyazofamid	50µM			permeabilized LUHMES cells	Assessment of the function of individual mitochondrial complexes using Agilent Seahorse XFe24		Positive	EC25(NA) [Glc/Gal]	326
Pentachlorophenol							Positive		253
acylindolones						increase	Positive		204
toxoflavin			rat	liver mitochondria	RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1	increase	Positive		204
tesimide			rat	liver mitochondria	RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1	increase	Positive		204
Menadione			rat	liver mitochondria	RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1	increase	Positive		204
tetracyclines							Positive		278
Ibuprofen							Positive		278
pirprofen							Positive		278
Flufenamic Acid							Positive		278
Diflunisal							Positive		278
Tolfenamic Acid							Positive		278
Diclofenac							Positive		278
2,4-dinitrophenol			rat	liver mitochondria	RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1	affect	Positive		204
Indomethacin							Positive		278
Naproxen							Positive		278
propranolol							Positive		278
amineptine							Positive		278
Tianeptine							Positive		278
pentamidine							Positive		278
imipramine							Positive		278
Chlorpromazine							Positive		278
Bupivacaine							Positive		278
buprenorphine							Positive		278
Perhexiline							Positive		278
Chloroquine							Positive		278
Fluoxetine							Positive		278
Propofol							Positive		278
Acetylsalicylic acid							Positive		278
Tamoxifen							Positive		278
Amiodarone							Positive		278
Tolcapone							Positive		278

F010501. Nonprotonophoric Uncouplers
F010502. protonophoric uncoupling
F010503. electrophoretic uncoupling