D0490 | benztropine mesylate
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| UNCOUPLING | rat | isolated liver mitochondria | measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay | increase | 53 | |||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
  |
Danger |
Aggregated GHS information provided by 75 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H300 (46.67%): Fatal if swallowed [Danger Acute toxicity, oral] H301 (52%): Toxic if swallowed [Danger Acute toxicity, oral] H311 (52%): Toxic in contact with skin [Danger Acute toxicity, dermal] H331 (52%): Toxic if inhaled [Danger Acute toxicity, inhalation] H370 (46.67%): Causes damage to organs [Danger Specific target organ toxicity, single exposure] H373 (46.67%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P260, P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P307+P311, P311, P312, P314, P321, P322, P330, P361, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| human | TDLo | oral | 100ug/kg (0.1mg/kg) | behavioral: toxic psychosis | Proceedings of the European Society for the Study of Drug Toxicity. Vol. 8, Pg. 59, 1967. |
| rat | LD50 | subcutaneous | 353mg/kg (353mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 208, 1972. | |
| guinea pig | LD50 | subcutaneous | 80mg/kg (80mg/kg) | autonomic nervous system: parasympatholytic | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 137, Pg. 375, 1962. |
| mouse | LD50 | oral | 91mg/kg (91mg/kg) | Drugs in Japan Vol. 6, Pg. 775, 1982. | |
| cat | LDLo | intravenous | 33mg/kg (33mg/kg) | Compilation of LD50 Values of New Drugs. | |
| mouse | LD50 | subcutaneous | 103mg/kg (103mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 208, 1972. | |
| mouse | LD50 | intraperitoneal | 65mg/kg (65mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 144, Pg. 555, 1963. | |
| rat | LD50 | oral | 940mg/kg (940mg/kg) | Drugs in Japan Vol. 6, Pg. 775, 1982. | |
| mouse | LD50 | intravenous | 24mg/kg (24mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 208, 1972. | |
| 1.alpha.H, 3.alpha.-(diphenylmethoxy)-, methanesulfonate | 102701-02-0 | 132-17-2 |
| 3-(Benzhydryloxy)-8-methyl-8-azabicyclo[3.2.1]octane methanesulfonate | 3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane, methanesulfonic acid | 3-Diphenylmethoxytropane mesylate |
| 3-Diphenylmethoxytropane methanesulfonate | 8-Azabicyclo[3.2.1]octane, endo-, methanesulfonate | AB0021001 |
| AK122005 | AKOS008105137 | AS-17846 |
| AX8001513 | B 8262 | BENZTROPINE MESYLATE |
| Benzatropine methanesulfonate | Benzophenone-3,3'-4,4'-tetracarboxylic dianhydrie | Benzotropine mesylate |
| Benzotropine methanesulfonate | Benzotropinemesylate | Benztropine (mesylate) |
| C21H25NO.CH4O3S | CCG-221498 | CHEMBL85236 |
| CPD000394012 | CS-2733 | CTK4B7776 |
| Cobrentin methanesulfonate | Cogentin mesylate | Cogentin methanesulfonate |
| EN300-51031 | EU-0100194 | HMS2747A15 |
| HMS3259P11 | HMS3260H09 | HMS3652K07 |
| HY-B0520A | KS-00000XL0 | LP00194 |
| MCULE-4736181346 | MK 02 | MLS000737056 |
| NC00646 | NCGC00016118-02 | NCGC00093670-01 |
| NCGC00260879-01 | NSC-169913 | NSC-42199 |
| NSC169913 | NSC42199 | Opera_ID_1229 |
| Q-200693 | SAM002548938 | SC-20236 |
| SCHEMBL41809 | SMR000394012 | SR-01000075303 |
| SR-01000075303-1 | SR-01000075303-5 | ST50997629 |
| Tox21_500194 | Tropine benzohydryl ether methanesulfonate | V2115 |
| WLN: T56 A ANTJ A1 GOYR & R & OSW1 | benzhydryl 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ether methanesulfonate; | benztropinemesylate |