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Drug

D0494 | protriptyline

Molecular Formula C19H21N
Molecular Weight 263.4
Structure
State solid
Route of elimination Protriptyline is reported to undergo cumulative urinary excretion during 16 days, which accounts for approximately 50% of the total drug administered. The fecal excretion pathway seems to play a minimal role in drug elimination.

N

N06AA11 Protriptyline


[N06AA] Non-selective monoamine reuptake inhibitors


[N06A] ANTIDEPRESSANTS


[N06] PSYCHOANALEPTICS


[N] Nervous system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
UNCOUPLING rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay increase 53

Organism Test type Route Dose (normalized dose) Effect Source
rabbit LD50 intravenous 8200mg/kg (8200mg/kg) Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
mouse LD50 oral 269mg/kg (269mg/kg) Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
mouse LD50 intraperitoneal 67mg/kg (67mg/kg) Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rat LD50 intraperitoneal 42mg/kg (42mg/kg) Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
mouse LD50 subcutaneous 192mg/kg (192mg/kg) Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rat LD50 oral 240mg/kg (240mg/kg) Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
mouse LD50 intravenous 30mg/kg (30mg/kg) behavioral: changes in motor activity (specific assay) Journal of Medicinal Chemistry. Vol. 17, Pg. 65, 1974.
rabbit LD50 oral 310mg/kg (310mg/kg) Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.


  • 3-(11H-dibenzo[1,2-a:1',2'-e][7]annulen-11-yl)-N-methylpropan-1-amine 3-(11H-dibenzo[[?],[?]][7]annulen-11-yl)-N-methyl-propan-1-amine 3-(5H-Dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine
    3-(5H-Dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine # 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine 438-60-8
    4NDU154T12 5-(3-Methylaminopropyl)-5H-Dibenzo[a,d]cycloheptene 5-(3-Methylaminopropyl)-5H-dibenzo(a,d)cycloheptene
    5H-Dibenzo(a,d)cycloheptene-5-propanamine, N-methyl- 5H-Dibenzo(a,d)cycloheptene-5-propylamine, N-methyl- 5H-Dibenzo[a, d]cycloheptene-5-propanamine, N-methyl-, hydrochloride
    5H-Dibenzo[a,d]cycloheptene-5-propanamine, N-methyl- 5H-Dibenzo[a,d]cycloheptene-5-propylamine, N-methyl- 7-(3-Methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene
    AB00489964 AB00489964_10 AC-15971
    ACM438608 AKOS015962184 Amimetilina
    BDBM50176062 BIDD:PXR0157 BPBio1_000924
    BRD-K42098891-003-03-1 BRN 2217411 BSPBio_000840
    BWPIARFWQZKAIA-UHFFFAOYSA-N C07408 CAS-1225-55-4
    CCG-205054 CHEBI:8597 CHEMBL668
    Concordin Concordin (Salt/Mix) D08447
    DB00344 DTXSID0023535 EINECS 207-119-9
    GTPL7285 HSDB 3391 L000913
    LS-60771 Lopac-P-8813 Lopac0_000974
    MCULE-6023848462 MK 240 MK-240
    Maximed N-3-(5H-Dibenzo(a,d)cyclohepten-5-yl)propyl-N-methylamine N-Methyl-5H-dibenzo(a,d)cycloheptene-5-propylamine
    N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine NCGC00015851-01
    NCGC00015851-02 NCGC00015851-03 NCGC00015851-04
    NCGC00015851-05 NCGC00015851-06 NCGC00015851-07
    NCGC00024439-03 NSC169912 Normethyl EX4442
    PDSP1_001390 PDSP2_001374 PROTRYPTYLINE HYDROCHLORIDE
    Prestwick0_000930 Prestwick1_000930 Prestwick2_000930
    Prestwick3_000930 Protriptilina Protriptilina [INN-Spanish]
    Protriptyline (INN) Protriptyline [INN:BAN] Protriptylinum
    Protriptylinum [INN-Latin] Protryptyline Q408432
    SBI-0050947.P002 SCHEMBL34267 SPBio_003019
    Triptil Triptil hydrochloride Triptyl
    UNII-4NDU154T12 Vivactil Vivactil (Salt/Mix)
    Vivactyl ZINC1530764 methyl(3-{tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-2-yl}propyl)amine;
    protriptyline

    DrugBank Name protriptyline
    DrugBank DB00344
    CAS Number 1225-55-4, 438-60-8
    PubChem Compound 4976
    KEGG Compound ID C07408
    KEGG Drug D08447
    ChEBI 8597
    PharmGKB PA451168