Compound
D0503 | aristolochic acid
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| OPENING OF PERMEABILITY TRANSITION PORE (PTP) | isolated kidney mitochondria | increase | 64 | |||||
| UNCOUPLING | rat | isolated liver mitochondria | measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay | Negative | 53 | |||
| ELECTRON TRANSPORT CHAIN | rat | isolated liver mitochondria | measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay | Negative | 53 | |||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
 |
Danger |
Aggregated GHS information provided by 42 companies from 4 notifications to the ECHA C&L Inventory. H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P270, P301+P310, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | intravenous | 40mg/kg (40mg/kg) | Farmakologiya i Toksikologiya Vol. 28, Pg. 74, 1965. | |
| rabbit | LDLo | intraperitoneal | 1500ug/kg (1.5mg/kg) | Farmakologiya i Toksikologiya Vol. 28, Pg. 74, 1965. | |
| mouse | LD50 | oral | 55900ug/kg (55.9mg/kg) | Archives of Toxicology. Vol. 59, Pg. 328, 1987. | |
| mouse | LD50 | intraperitoneal | 14320ug/kg (14.32mg/kg) | Guangxi Yixue. Kuanghsi Medicine. Vol. (6), Pg. 2, 1981. | |
| man | LDLo | intravenous | 3mg/kg/2D-I (3mg/kg) | kidney, ureter, and bladder: "changes in tubules (including acute renal failure, acute tubular necrosis)" | Cancer Chemotherapy Reports. Vol. 42, Pg. 35, 1964. |
| mouse | LD50 | intravenous | 38400ug/kg (38.4mg/kg) | Archives of Toxicology. Vol. 59, Pg. 328, 1987. | |
| rat | LD50 | oral | 184mg/kg (184mg/kg) | Archives of Toxicology. Vol. 59, Pg. 328, 1987. | |
| rat | LD50 | intravenous | 74mg/kg (74mg/kg) | Archives of Toxicology. Vol. 59, Pg. 328, 1987. | |
| 3,4-Methylenedioxy-8-methoxy-10-nitro-1-phenanthrenecarboxylic acid | 313-67-7 | 313A677 |
| 61117-05-3 | 8-METHOXY-6-NITROPHENANTHROL(3,4-D)-1,3-DIOXIDE-5- | 8-METHOXY-6-NITROPHENANTHROL(3,4-D)-1,3-DIOXIDE-5-CARBOXYLIC ACID |
| 8-Methoxy-3,4-methylendioxxy-10-nitro-1-phenanthrencarbonsaeure | 8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid | 8-Methoxy-6-nitro-phenanthro[3,4-d][1,3]dioxole-5-carboxylic acid |
| 8-Methoxy-6-nitrophenanthol (3,4-d) 1,3-dioxole-5-carboxylic acid | 8-Methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid | 8-Methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid # |
| 8-methoxy-6-nitro-2H-phenanthro[3,4-d]1,3-dioxolene-5-carboxylic acid | 8-methoxy-6-nitro-2H-phenanthro[4,3-d]1,3-dioxolene-5-carboxylic acid | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid |
| 8-methoxy-6-nitro-naphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid | 8-methoxy-6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid | 8-methoxy-6-nitrophenanthro(3,4-d)-1,3-dioxole-5-carboxylic acid |
| 94218WFP5T | A000071790 | AB0028965 |
| AK168151 | AKOS015896751 | API0000398 |
| ARISTOLOCHINE | Aristolochia, European Pharmacopoeia (EP) Reference Standard | Aristolochiazaeure |
| Aristolochic acid | Aristolochic acid 1 | Aristolochic acid A |
| Aristolochic acid A,(S) | Aristolochic acid I | Aristolochic acid I, European Pharmacopoeia (EP) Reference Standard |
| Aristolochic acid I, powder | Aristolochic acid, 96%, mixture of I and II | Aristolochic acid-I |
| Aristolochic-acid-A | Aristolochin | BBFQZRXNYIEMAW-UHFFFAOYSA-N |
| BDBM50306855 | BRN 0345159 | BSPBio_001440 |
| BSPBio_002848 | Bio1_000418 | Bio1_000907 |
| Bio1_001396 | Bio2_000160 | Bio2_000640 |
| Birthwort | C-20352 | C08469 |
| C17H11NO7 | CC-24181 | CCG-35796 |
| CCG-36162 | CCRIS 1544 | CHEBI:2825 |
| CHEMBL93353 | CS-0009050 | CTK4G6973 |
| DB-048017 | DTXSID0040969 | DivK1c_006544 |
| EINECS 206-238-3 | FT-0602867 | GOQ; |
| HMS1361H22 | HMS1791H22 | HMS1989H22 |
| HMS3402H22 | HSDB 7179 | HY-N0510 |
| IDI1_033910 | KBio1_001488 | KBio2_000160 |
| KBio2_001636 | KBio2_002728 | KBio2_004204 |
| KBio2_005296 | KBio2_006772 | KBio3_000319 |
| KBio3_000320 | KBio3_002068 | KBioGR_000160 |
| KBioGR_002387 | KBioSS_000160 | KBioSS_001636 |
| LS-21656 | MCULE-3861334509 | MFCD00004996 |
| MLS002695974 | MLS002702976 | N2032 |
| NCGC00017334-01 | NCGC00017334-02 | NCGC00017334-03 |
| NCGC00017334-04 | NCGC00017334-05 | NCGC00017334-06 |
| NCGC00017334-07 | NCGC00095981-01 | NCGC00095981-02 |
| NCGC00095981-03 | NCGC00095981-04 | NCGC00095981-05 |
| NCI60_000460 | NCIMech_000812 | NSC 11926 |
| NSC 50413 | NSC-11926 | NSC-50413 |
| NSC11926 | NSC50413 | Phenanthro(3,4-d)-1,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitro- |
| Phenanthro[3,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitro- | Phenanthro[3,4-d]-1,3-dioxole-5-carbocylic acid, 8-methoxy-6-nitro- | Phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitro- |
| Q-100394 | Q21099362 | SC-14173 |
| SCHEMBL166284 | SMR001562128 | SPBio_000743 |
| SPECTRUM1502233 | SR-05000002369 | SR-05000002369-2 |
| SR-05000002369-3 | ST057179 | ST50307164 |
| SpecPlus_000448 | Spectrum2_000822 | Spectrum3_001114 |
| Spectrum4_001952 | Spectrum5_000729 | Spectrum_001156 |
| TNP00273 | TR 1736 | TR-013344 |
| Tardolyt | UNII-94218WFP5T | X1086 |
| ZINC52 | aris-tolochic acid | s9193 |