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Drug

D1426 | amphotericin B

Molecular Formula C47H73NO17
Molecular Weight 924.1
Structure
State solid
Clearance * 39 +/- 22 mL/hr/kg [febrile neutropenic cancer and bone marrow transplant patients receiving infusion of 1 mg/kg/day at Day 1] * 17 +/- 6 mL/hr/kg [febrile neutropenic cancer and bone marrow transplant patients receiving infusion of 1 mg/kg/day 3-20 days later] * 51 +/- 44 mL/hr/kg [febrile neutropenic cancer and bone marrow transplant patients receiving infusion of 2.5 mg/kg/day at Day 1] * 22 +/- 15 mL/hr/kg [febrile neutropenic cancer and bone marrow transplant patients receiving infusion of 2.5 mg/kg/day 3-20 days later] * 21 +/- 14 mL/hr/kg [febrile neutropenic cancer and bone marrow transplant patients receiving infusion of 5 mg/kg/day at Day 1] * 11 +/- 6 mL/hr/kg [febrile neutropenic cancer and bone marrow transplant patients receiving infusion of 5 mg/kg/day 3-20 days later]
Protein binding Highly bound (>90%) to plasma proteins.
Half life An elimination half-life of approximately 15 days follows an initial plasma half-life of about 24 hours.
Absorption Bioavailability is 100% for intravenous infusion.
Description antifungal

G

J

A

J02AA01 Amphotericin b


[J02AA] Antibiotics


[J02A] ANTIMYCOTICS FOR SYSTEMIC USE


[J02] ANTIMYCOTICS FOR SYSTEMIC USE


[J] Antiinfectives for systemic use

G01AA03 Amphotericin b


[G01AA] Antibiotics


[G01A] ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS


[G01] GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS


[G] Genitourinary system and reproductive hormones

A07AA07 Amphotericin b


[A07AA] Antibiotics


[A07A] INTESTINAL ANTIINFECTIVES


[A07] ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS


[A] Alimentary tract and metabolism

A01AB04 Amphotericin b


[A01AB] Antiinfectives and antiseptics for local oral treatment


[A01A] STOMATOLOGICAL PREPARATIONS


[A01] STOMATOLOGICAL PREPARATIONS


[A] Alimentary tract and metabolism

Toxicity Dose Time Species Model Method Action Positive criterion Reference
LIPID PEROXIDATION 2.5mg/ml Aspergillus fumigatus the formation of MDAs by antifungal drug-derived ROS in A. fumigatus was determined using the thiobarbituric acid (TBA) assay. induce 304
LIPID PEROXIDATION 2.5mg/ml Aspergillus fumigatus mitochondrion-specific lipid peroxidation probe MitoPerOx induce 304
ROS PRODUCTION 2.5mg/ml Aspergillus fumigatus oxidant-sensing fluorescent probe 2′,7′-dichlorofluorescin diacetate t induce 304


  • DrugBank DB00681
    PubChem Compound 5386092