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F02010204 | Maximal respiration


Function of mitochondria >> Respiration >> Mitochondrial parameters >> maximal respiration

Compound Dose Time Species Model Method Action Result Positive criterion Reference
tacrolimus 50 µg/ml 12hr INS-1 cells XF24 Extracellular Flux Analyzer decrease Positive 322
xanthone 20 µM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 86
2,4-dinitrophenol 0.5 μM / 24 hpf zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 90
triclosan 30 μM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 89
quercetin 1 µg/l zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 91
fluoranthene 100 µg/l zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 85
diquat 100 μM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 92
Phenanthrenequinone 2 µM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 86
Metformin 2mM 30 minutes mouse; C57BL/6J isolated skeletal muscle mitochondria Measurement of Oxygen level; incubated in complex I substrate; added FCCP (1.5 μM) decrease Positive p < 0.05 172
benz(a)anthracene-7,12-dione 5 µM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 86
1,9-benz-10-anthrone 10 µM zebrafish XFe24 Extracellular Flux Analyzer decrease Positive 86