F021101 | Metabolite transport

Compound Dose Time Species Model Method Action Result Positive criterion Reference
lovastatin C2C12 myoblasts affect Positive 180
Simvastatin C2C12 myoblasts affect Positive 180
thiazolidinediones decrease Positive 35
thiazolidinediones decrease Positive 34
1h-benzimidazol-5-amine-2-4-aminophenyl ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-(Dimethylamino)-1,3-benzothiazol-6-ol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)amino]phenol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
7,8-Dihydroxy-4-methylcoumarin ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-Amino-2-(5-ethyl-benzooxazol-2-yl)-phenol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
(4-Methoxyphenyl)-[2-(p-anisidino)ethyl]amine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
3,3'-Diamino-4,4'-dihydroxydiphenyl Sulfone ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-(4-Hydroxy-1H-indol-3-yl)acetamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2,5-Bis(2-phenylacetamido)terephthalic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2,6-Dimethyl-5,12-dihydroindolo[3,2-d][1,3]benzodiazepine;hydrochloride ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-(4-{[(4,6-Dimethyl-2-pyrimidinyl)amino]sulfonyl}phenyl)-2,4-dimethoxybenzamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N'-(4-Methoxybenzyl)-N,N-dimethylbenzene-1,3-diamine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-(1,2,3,4-Tetrahydro-benzo[a]phenanthridin-5-yl)-benzene-1,2-diol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-Benzyl-4-methoxyaniline ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
Methyl 2-amino-4-ethyl-5-methylthiophene-3-carboxylate ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-(4-(4-Methyl-1-piperazinyl)phenyl)-9-acridinamine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-Chloro-N-(2-hydroxyphenyl)benzenesulfonamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-(4-Hydroxyphenyl)furan-2-carboxamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
(Z)-2-Cyano-3-(3-ethoxy-4-hydroxyphenyl)prop-2-enamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
(3-Bromo-4-hydroxyphenyl)[(4-chlorophenyl)sulfonyl]amine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-Chloro-6-methylindolo[1,2-c]quinazolin-12-amine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-(2,3-Dihydro-1H-benzo[f]cyclopenta[c]quinolin-4-yl)benzene-1,2-diol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
(5E)-5-(4-Hydroxybenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
8-Chloro-2,2-dimethyl-2,3-dihydro-1H-phenothiazin-4(10H)-one ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-[(3,4-Dimethylphenyl)sulfonyl]benzene-1,4-diol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-([4-(1H-Benzimidazol-2-yl)phenyl]amino)-4-oxobutanoic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
Ethyl 2-ethoxy-5-hydroxy-1H-indole-3-carboxylate ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-(1,2,3,4-Tetrahydrobenzo[a]phenanthridin-5-yl)benzene-1,3-diol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-(Cyclohexylmethyl)-4-methoxyaniline ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-(Furan-2-ylmethyl)-1,3-benzodioxol-5-amine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
5-Nitro-2-phenyl-1H-indole ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
8-Chloro-2,3-dihydro-1H-phenothiazin-4(10H)-one ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-(4-Bromophenyl)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-[2-(2-Aminophenyl)vinyl]-5,7-dimethylquinolin-8-ol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4,6-Dimethyl-2-phenyl-2H-pyrazolo[3,4-b]pyridin-3-ol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-Methoxy-2-[(4-piperidylpiperidyl)methyl]phenol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-(5-Isopropyl-1,3,4-thiadiazol-2-yl)-3-nitrobenzamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-Amino-6-ethyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
(NE)-N-[[3-[[3-[(E)-hydroxyiminomethyl]-2,4,6-trimethylphenyl]methyl]-2,4,6-trimethylphenyl]methylidene]hydroxylamine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-(3-Fluorophenyl)-2,4,6-tri(propan-2-yl)benzenesulfonamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-(4-Hydroxy-3-methoxybenzylidene)-1H-indene-1,3(2H)-dione ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-Furancarboxamide, N-[[(4-methoxyphenyl)amino]thioxomethyl]- ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-Amino-N-quinolin-8-yl-benzenesulfonamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
(5Z)-5-[(4-Fluorophenyl)methylidene]-1-methyl-3-phenyl-1,3-diazinane-2,4,6-trione ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-[4-(1-Adamantyl)phenoxy]-N,N-diethylethanamine;hydrochloride ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
(2Z)-2-(Acetylamino)-N-(4-hydroxyphenyl)-3-phenylprop-2-enamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
(5E)-5-[(3-Bromo-4-methoxyphenyl)methylidene]-1-phenyl-2-sulfanylidene-1,3-diazinane-4,6-dione ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
[(3-{[(4-Bromophenyl)amino]carbonyl}phenyl)thio]acetic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-[(4-Chlorobenzyl)thio]-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
1-(5-Hydroxy-2-methyl-1-phenyl-1H-indol-3-yl)ethanone ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-[(4-Ethylpiperazin-1-yl)methyl]-4-methoxyphenol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-(4-Fluorophenyl)-1,3,5-trimethyl-2,6-diphenylpiperidin-4-ol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-[(E)-1-[5-(4-Bromophenyl)furan-2-yl]-3-[3-(dimethylamino)propylamino]-3-oxoprop-1-en-2-yl]-4-methylbenzamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
(2Z)-3-{N-[4-(4-Chlorophenyl)phenyl]carbamoyl}prop-2-enoic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-[(E)-3-(4-Ethylpiperazin-1-yl)prop-1-enyl]-N,N-dimethylaniline ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
1,5-Dihydro-4,5-diphenyl-2H-imidazol-2-one ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-[(E)-2-(4-Chlorophenyl)ethenyl]-1-methyl-1H-benzimidazole ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-[1-Azabicyclo[2.2.2]octan-3-ylidene-[4-(dimethylamino)phenyl]methyl]-N,N-dimethylaniline;hydrochloride ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-Oxo-4-((4-(styryl)phenyl)amino)but-2-enoic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2,5-Dianilinoterephthalic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-Methoxy-N-[4-(thiazol-2-ylsulfinamoyl)-phenyl]-benzamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
3-[(3,4-Dimethylphenyl)sulfonyl]propanenitrile ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-[4-(1,3-Benzoxazol-2-yl)anilino]-4-oxobutanoic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
1-(3-Chlorophenyl)-2,3,4,5,6,7,8,8a-octahydro-1H-isoquinolin-4a-ol;hydrochloride ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
6-Methyl-2-(1,2,2,2-tetrafluoroethyl)-1H-benzimidazole ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
Ethyl 6-amino-5-cyano-2-methyl-4-(2-nitrophenyl)-4H-pyran-3-carboxylate ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-(2,1,3-Benzoxadiazol-4-yl)-2,2,2-trifluoroacetamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-Tert-butyl-N-(4-methylphenyl)benzamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-Methoxy-4-(morpholin-4-ylmethyl)phenol ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
Bis((1E)-2-phenylvinyl)phosphinic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
1-[2-(Allyloxy)benzyl]-4-benzylpiperidine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2,5-Diaminoterephthalic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-(1-Adamantylcarbonyl)-N'-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)thiourea ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-(Isobutylthio)succinic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-{4-[Acetyl(methyl)amino]phenyl}-4-biphenylcarboxamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
4-[(E)-3-(2-Ethylpiperidin-1-yl)prop-1-enyl]-N,N-dimethylaniline ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
3-(2-Chloro-phenyl)-2-(4-(2-oxo-2H-chromen-3-YL)-thiazol-2-YL)-acrylonitrile ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
Ethyl (7Z)-2-amino-7-(hydroxyimino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-Amino-4-(3,4-dichlorophenyl)thiazole ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
5-(2-Nitrobenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
3-(4-Bromo-2-thienyl)-2-cyano-2-propenethioamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
Benzyl [(6-amino-3,5-dicyano-4-ethylpyridin-2-yl)sulfanyl]acetate ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
N-{2-[(1,3-Diphenyl-1H-pyrazol-5-yl)amino]phenyl}benzamide ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-Butyl-5-methylisophthalic acid ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-Butylsulfanyl-6-methyl-9H-1,3,4,9-tetraaza-fluorene ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
2-Phenyldipyrrolo[1,2-a:2',1'-c]pyrazine ∼2.5 µM rat skeletal muscle mitochondria measurement of superoxide/H2O2 production affect Positive 162
Valproic Acid 0.5–2 mM 3min rat inverted submitochondrial vesicles (ISMV) from rat liver isolated mitochondria The rate of the radiolabeled substrate [1-14C]-pyruvate uptake by ISMV was measured in the presence or absence of an inwardly directed proton gradient. inhibitor Positive 279
alpha-Cyano-4-hydroxycinnamate 1mM 3min rat inverted submitochondrial vesicles (ISMV) from rat liver isolated mitochondria The rate of the radiolabeled substrate [1-14C]-pyruvate uptake by ISMV was measured in the presence or absence of an inwardly directed proton gradient. inhibitor Positive 279
alpha-Cyano-4-hydroxycinnamate 0.05mM inhibitor Positive >90% inhibition 280
Alpha-Cyanocinnamate 0.05mM inhibitor Positive >90% inhibition 280