F02110112 | Transport of pyruvate
| Compound | Dose | Time | Species | Model | Method | Action | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|---|
| thiazolidinediones | decrease | Positive | 35 | ||||||
| Valproic Acid | 0.5–2 mM | 3min | rat | inverted submitochondrial vesicles (ISMV) from rat liver isolated mitochondria | The rate of the radiolabeled substrate [1-14C]-pyruvate uptake by ISMV was measured in the presence or absence of an inwardly directed proton gradient. | inhibitor | Positive | 279 | |
| alpha-Cyano-4-hydroxycinnamate | 1mM | 3min | rat | inverted submitochondrial vesicles (ISMV) from rat liver isolated mitochondria | The rate of the radiolabeled substrate [1-14C]-pyruvate uptake by ISMV was measured in the presence or absence of an inwardly directed proton gradient. | inhibitor | Positive | 279 | |
| alpha-Cyano-4-hydroxycinnamate | 0.05mM | inhibitor | Positive | >90% inhibition | 280 | ||||
| Alpha-Cyanocinnamate | 0.05mM | inhibitor | Positive | >90% inhibition | 280 | ||||
| thiazolidinediones | decrease | Positive | 34 | ||||||