F021202 | NADPH metabolism
GO:0006739
map00480
R-HSA-389542
Function of mitochondria >> Metabolism of cofactors and vitamins >> NADPH metabolism
Function of mitochondria >> Metabolism of cofactors and vitamins >> NADPH metabolism
| Compound | Dose | Time | Species | Model | Method | Action | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Nimesulide | 1 mM | rat; Sprague-Dawley Crl:CD (SD) BR | lung microsomes | measurement of NADPH oxidation | increase | Positive | p < 0.05 | 11 | |
| Diclofenac | 50 μmol/L | 10 minutes | rat | liver mitochondria | Measurement of Mitochondrial NADPH; incubated in the presence of Ca2+ | increase | Positive | p < 0.01 | 6 |