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T022 Source: Uniprot

enzymeCarnitine O-palmitoyltransferase 2, mitochondrial, EC 2.3.1.21 (CPT-II)
Transferase Acyltransferase
Full Name Carnitine O-palmitoyltransferase 2, mitochondrial, EC 2.3.1.21
Protein Names Carnitine O-palmitoyltransferase 2, mitochondrial (EC 2.3.1.21) (Carnitine palmitoyltransferase II) (CPT II)
Subcellular Location Matrix side Mitochondrion inner membrane Peripheral membrane protein
EC numbers 2.3.1.21
Uniprot Accession P23786
Uniprot Name CPT2_HUMAN
Gene symbol CPT2
Gene Name Carnitine palmitoyltransferase 2
Ensembl ENSG00000157184

Compound Dose Time Species Model Method Result Positive criterion Reference
palmitoylaminocarnitine 0.14 human/rat recombinant Pichia pastoris Membrane Preparations spectrophotometric assay with DTNB Positive IC50 (μM) 333
ST1326 0.16/0.38 human/rat recombinant Pichia pastoris Membrane Preparations spectrophotometric assay with DTNB Positive IC50 (μM) 333
ST2425 5.4/− human/rat recombinant Pichia pastoris Membrane Preparations spectrophotometric assay with DTNB Positive IC50 (μM) 333
Trimetazidine >100/− human/rat recombinant Pichia pastoris Membrane Preparations spectrophotometric assay with DTNB Negative IC50 (μM) 333
Perhexiline 72.8/− human/rat recombinant Pichia pastoris Membrane Preparations spectrophotometric assay with DTNB Positive IC50 (μM) 333
Amiodarone >100/− human/rat recombinant Pichia pastoris Membrane Preparations spectrophotometric assay with DTNB Negative IC50 (μM) 333
Oxfenicine >100/− human/rat recombinant Pichia pastoris Membrane Preparations spectrophotometric assay with DTNB Negative IC50 (μM) 333
oxfenicine metabolite >100/− human/rat recombinant Pichia pastoris Membrane Preparations spectrophotometric assay with DTNB Negative IC50 (μM) 333
Perhexiline Positive 16
RO-25-0187 4.7/>100 human/rat recombinant Pichia pastoris Membrane Preparations spectrophotometric assay with DTNB Positive IC50 (μM) 333
Perhexiline Positive 17
aminocarnitine 3.9/5.1 human/rat recombinant Pichia pastoris Membrane Preparations spectrophotometric assay with DTNB Positive IC50 (μM) 333

F02060101. mitochondrial fatty acid beta oxidation