Compound	Dose	Time	Species	Model	Method	Result	Positive criterion	Reference
N-deacetyl ketoconazole	20 μM	0.5 hours	rat	hepatocytes	Measurement of LDH activities	Negative	p < 0.05	8
N-deacetyl ketoconazole	40 μM	0.5 hours	rat	hepatocytes	Measurement of LDH activities	Negative	p < 0.05	8
N-deacetyl ketoconazole	60 μM	0.5 hours	rat	hepatocytes	Measurement of LDH activities	Negative	p < 0.05	8
N-deacetyl ketoconazole	80 μM	0.5 hours	rat	hepatocytes	Measurement of LDH activities	Negative	p < 0.05	8
N-deacetyl ketoconazole	120 μM	0.5 hours	rat	hepatocytes	Measurement of LDH activities	Positive	p < 0.05	8
N-deacetyl ketoconazole	160 μM	0.5 hours	rat	hepatocytes	Measurement of LDH activities	Positive	p < 0.05	8
N-deacetyl ketoconazole	20 μM	1 hours	rat	hepatocytes	Measurement of LDH activities	Negative	p < 0.05	8
N-deacetyl ketoconazole	40 μM	1 hours	rat	hepatocytes	Measurement of LDH activities	Negative	p < 0.05	8
N-deacetyl ketoconazole	60 μM	1 hours	rat	hepatocytes	Measurement of LDH activities	Negative	p < 0.05	8
N-deacetyl ketoconazole	80 μM	1 hours	rat	hepatocytes	Measurement of LDH activities	Negative	p < 0.05	8
N-deacetyl ketoconazole	120 μM	1 hours	rat	hepatocytes	Measurement of LDH activities	Positive	p < 0.05	8
N-deacetyl ketoconazole	160 μM	1 hours	rat	hepatocytes	Measurement of LDH activities	Positive	p < 0.05	8
N-deacetyl ketoconazole	20 μM	2 hours	rat	hepatocytes	Measurement of LDH activities	Negative	p < 0.05	8
N-deacetyl ketoconazole	40 μM	2 hours	rat	hepatocytes	Measurement of LDH activities	Negative	p < 0.05	8
N-deacetyl ketoconazole	60 μM	2 hours	rat	hepatocytes	Measurement of LDH activities	Negative	p < 0.05	8
N-deacetyl ketoconazole	80 μM	2 hours	rat	hepatocytes	Measurement of LDH activities	Positive	p < 0.05	8
N-deacetyl ketoconazole	120 μM	2 hours	rat	hepatocytes	Measurement of LDH activities	Positive	p < 0.05	8
N-deacetyl ketoconazole	160 μM	2 hours	rat	hepatocytes	Measurement of LDH activities	Positive	p < 0.05	8
N-deacetyl ketoconazole	20 μM	4 hours	rat	hepatocytes	Measurement of LDH activities	Negative	p < 0.05	8
N-deacetyl ketoconazole	40 μM	4 hours	rat	hepatocytes	Measurement of LDH activities	Negative	p < 0.05	8
N-deacetyl ketoconazole	60 μM	4 hours	rat	hepatocytes	Measurement of LDH activities	Positive	p < 0.05	8
N-deacetyl ketoconazole	80 μM	4 hours	rat	hepatocytes	Measurement of LDH activities	Positive	p < 0.05	8
N-deacetyl ketoconazole	120 μM	4 hours	rat	hepatocytes	Measurement of LDH activities	Positive	p < 0.05	8
N-deacetyl ketoconazole	160 μM	4 hours	rat	hepatocytes	Measurement of LDH activities	Positive	p < 0.05	8
N-deacetyl ketoconazole	120 μM	0.5 hours	rat	hepatocytes	Measurement of LDH activities; co-treatment of 250 μM n-Octylamine	Positive	p < 0.05	8
N-deacetyl ketoconazole	120 μM	0.5 hours	rat	hepatocytes	Measurement of LDH activities; co-treatment of 100 μM Methimazole	Positive	p < 0.05	8
N-deacetyl ketoconazole	120 μM	1 hours	rat	hepatocytes	Measurement of LDH activities; co-treatment of 250 μM n-Octylamine	Positive	p < 0.05	8
N-deacetyl ketoconazole	120 μM	1 hours	rat	hepatocytes	Measurement of LDH activities; co-treatment of 100 μM Methimazole	Positive	p < 0.05	8
N-deacetyl ketoconazole	160 μM	1 hours	rat	hepatocytes	Measurement of LDH activities; co-treatment of 250 μM n-Octylamine	Positive	p < 0.05	8
N-deacetyl ketoconazole	160 μM	1 hours	rat	hepatocytes	Measurement of LDH activities; co-treatment of 100 μM Methimazole	Positive	p < 0.05	8

T076001. L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59)
T076002. L-lactate dehydrogenase A-like 6B (EC 1.1.1.27)
T076003. L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46)
T076004. L-lactate dehydrogenase C chain (LDH-C) (EC 1.1.1.27) (Cancer/testis antigen 32) (CT32) (LDH testis subunit) (LDH-X)

F0701. Apoptosis
F020201. generation of lactate
F020401. glycolysis