GO:0006007 map00010 R-HSA-70171
Function of mitochondria >> Glucose metabolism >> glycolysis

Related Drugs/Compounds

Compound	Dose	Time	Species	Model	Method	Action	Result	Positive criterion	Reference
Tolcapone	3.7 μM	2 minutes	human	HepG2	Measurement of ECAR	increase	Positive	EC50	7
2-Deoxy-D-glucose							Positive		249
Entacapone	100 μM	2 minutes	human	HepG2	Measurement of ECAR	increase	Positive	EC50	7
Lonidamine							Positive		249
3-Bromopyruvate							Positive		249
Imatinib							Positive		249
Oxythiamine							Positive		249
Nilutamide	79 μM	2 minutes	human	HepG2	Measurement of ECAR	increase	Positive	EC50	7
Flutamide	> 100 μM	2 minutes	human	HepG2	Measurement of ECAR	increase	Positive	EC50	7
Chlorpromazine	> 300 μM	2 minutes	human	HepG2	Measurement of ECAR	increase	Positive	EC50	7
Diflunisal	30 μM	2 minutes	human	HepG2	Measurement of ECAR	increase	Positive	EC50	7
Benoxaprofen	> 100 μM	2 minutes	human	HepG2	Measurement of ECAR	increase	Positive	EC50	7
Troglitazone	> 100 μM	2 minutes	human	HepG2	Measurement of ECAR	increase	Positive	EC50	7
Ciglitazone	> 100 μM	2 minutes	human	HepG2	Measurement of ECAR	increase	Positive	EC50	7
Troglitazone	10 μM	2 minutes	feline	cardiomyocytes	Measurement of ECAR	increase	Positive	EC50	7
Ciglitazone	10 μM	2 minutes	feline	cardiomyocytes	Measurement of ECAR	increase	Positive	EC50	7
Rosiglitazone	> 100 μM	2 minutes	feline	cardiomyocytes	Measurement of ECAR	increase	Positive	EC50	7
Trimetazidine						increase	Positive		17
ranolazine						increase	Positive		17
Pioglitazone							Positive		21
2,4-dinitrophenol						increase	Positive		24
2-Deoxy-D-glucose			human	SkBr3 breast cancer cells	MTT assay	decrease	Positive		25
buformin	25 μM	24 hours	human	HepG2 cells	Measurement of ECAR	increase	Positive	p < 0.001	15
Phenformin	25 μM	24 hours	human	HepG2 cells	Measurement of ECAR	increase	Positive	p < 0.001	15
Oligomycin	1.1±0.23 μM	2 minutes	human	HepG2	Measurement of ECAR	increase	Positive	EC50	7
Metformin	5 mM	24 hours	mouse	NMuMG	Meassurement of glucose concentration	increase	Positive	p < 0.05	172
Clotrimazole						decrease	Positive		35
Metformin	5 mM	24 hours	mouse	NT2196	Meassurement of glucose concentration	increase	Positive	p < 0.05	172
Metformin	5 mM	24 hours	human	MCF10A	Meassurement of glucose concentration	increase	Positive	p < 0.05	172
Metformin	5 mM	24 hours	human	MCF7	Meassurement of glucose concentration	increase	Positive	p < 0.05	172
Metformin	5 mM	24 hours	mouse	NT2196	Meassurement of lactate concentration	increase	Positive	p < 0.05	172
Metformin	5 mM	24 hours	human	MCF10A	Meassurement of lactate concentration	increase	Positive	p < 0.05	172
Metformin	5 mM	48 hours	mouse	NMuMG	Meassurement of glucose concentration	increase	Positive	p < 0.05	172
Metformin	5 mM	48 hours	mouse	NT2196	Meassurement of glucose concentration	increase	Positive	p < 0.05	172
Metformin	5 mM	48 hours	human	MCF10A	Meassurement of glucose concentration	increase	Positive	p < 0.05	172
Metformin	5 mM	48 hours	human	MCF7	Meassurement of glucose concentration	increase	Positive	p < 0.05	172
Metformin	5 mM	24 hours	human	MCF7	Meassurement of lactate concentration	increase	Positive	p < 0.05	172
Metformin	5 mM	48 hours	mouse	NMuMG	Meassurement of lactate concentration	increase	Positive	p < 0.05	172
Metformin	5 mM	48 hours	mouse	NT2196	Meassurement of lactate concentration	increase	Positive	p < 0.05	172
Metformin	5 mM	48 hours	human	MCF10A	Meassurement of lactate concentration	increase	Positive	p < 0.05	172
Metformin	5 mM	48 hours	human	MCF7	Meassurement of lactate concentration	increase	Positive	p < 0.05	172
Rotenone	371±58 nM	2 minutes	human	HepG2	Measurement of ECAR	increase	Positive	EC50	7
Antimycin A	100±20 nM	2 minutes	human	HepG2	Measurement of ECAR	increase	Positive	EC50	7
iodoacetate						inhibition	Positive		278
Dichloroacetate						inhibition	Positive		278
FCCP	141±20 nM	2 minutes	human	HepG2	Measurement of ECAR	increase	Positive	EC50	7
2-Deoxy-D-glucose	150 mM	2 minutes	human	HepG2	Measurement of ECAR	decrease	Positive	EC50	7
2-Deoxy-D-glucose						decrease	Positive		35

Involved Pathways

F02040101. ECAR
F02040102. glucose consumption
F02040103. lactate production

Associated Targets

T067. Hexokinase-1
T072. Glyceraldehyde-3-phosphate dehydrogenase
T080. Pyruvate dehydrogenase kinase