T118 Source: Uniprot
enzymePeptidyl-prolyl cis-trans isomerase F, mitochondrial
(PPIase F)
Rotamase
Isomerase
| Full Name | Peptidyl-prolyl cis-trans isomerase F, mitochondrial |
|---|---|
| Protein Names | Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin D) (CyP-D) (CypD) (Cyclophilin F) (Mitochondrial cyclophilin) (CyP-M) (Rotamase F) |
| Subcellular Location | Mitochondrion matrix |
| EC numbers | 5.2.1.8 |
| Uniprot Accession | P30405 |
| Uniprot Name | PPIF_HUMAN |
| Gene symbol | PPIF |
| Gene Name | Peptidylprolyl isomerase F |
| Ensembl | ENSG00000108179 |
| Compound | Dose | Time | Species | Model | Method | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Cyclosporin A | 5 μM | mouse embryonic fibroblasts (MEFs) and SH-SY5Y cells | Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye | Positive | 252 | |||
| JW47 | 504.5 ± 9.2 nM (CypA), 298.0 ± 17.9 nM( K133I CypD) | Fluorescence Polarization Assay to measure affinity of ligands to cyclophilins (fluorescein-PEG-CsA ligand as the probe) | Positive | Ki | 324 | |||
| Cyclosporin A | 22.5 ± 4.3nM (CypA), 1.4 ± 1.6 nM( K133I CypD) | Fluorescence Polarization Assay to measure affinity of ligands to cyclophilins (fluorescein-PEG-CsA ligand as the probe) | Positive | Ki | 324 | |||