GO:0000423 map04137 R-HSA-5205647
Organization of mitochondria >> Mitochondrial dynamics >> mitophagy

Related Drugs/Compounds

Compound	Dose	Time	Species	Model	Method	Action	Result	Positive criterion	Reference
Wortmannin	100 nM			SH-SY5Y neuroblastoma cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.		Positive		252
hydroxychloroquine	30 μM			SH-SY5Y neuroblastoma cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.		Positive		252
3-methyladenine	10 mM			SH-SY5Y neuroblastoma cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.		Positive		252
Bafilomycin A1	50 nM			SH-SY5Y neuroblastoma cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.		Positive		252
CCCP	10 μM or 25 μM			mouse embryonic fibroblasts (MEFs) and SH-SY5Y cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.		Positive		252
earle’s balanced salt solution							Positive		252
rapamycin			mouse	embryonic retinas	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye		Positive		252
Urolithin A						enhance	Positive		248
Cyclosporin A	5 μM			mouse embryonic fibroblasts (MEFs) and SH-SY5Y cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye	block	Positive		252
Nicotinamide	5 mM	6h		SH-SY5Y cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.	induce	Positive		252
fisetin	10 μM	6h		SH-SY5Y cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.	induce	Positive		252
Xanthohumol	30μM	24hr		MCF7 cells	using the MAP1LC3II/I ratio to monitor the autophagic flux; quantifiedPMPCB staining	block	Positive		283

Associated Targets

T118. Peptidyl-prolyl cis-trans isomerase F, mitochondrial
T260. Prohibitin-2
T416. Serine/threonine-protein kinase mTOR