Database
User
| Full Name | mCU (mitochondrial calcium uniporter) |
|---|---|
| Protein Names | Calcium uniporter protein, mitochondrial, HsMCU (Coiled-coil domain-containing protein 109A) |
| Subcellular Location | Mitochondrion inner membrane Multi-pass membrane protein |
| Uniprot Accession | Q8NE86 |
| Uniprot Name | MCU_HUMAN |
| Gene symbol | MCU |
| Gene Name | Mitochondrial calcium uniporter |
| Ensembl | ENSG00000156026 |
| Compound | Dose | Time | Species | Model | Method | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| DS16570511 | 7 μM | HEK293A cells | HEK293A cell lines expressing the mitochondria-targeted Ca2+ indicator protein aequorin | Positive | IC50 | 302 | ||
| SB202190 | 10 μM | intact and in permeabilized HeLa cells (MM5 cells expressing mitmutAEQ ) | mitochondrial Ca2+ uptake | Positive | 233 | |||
| kaempferol | 1μM | The HeLa cell clone MM5 expressing mitochondrially targeted mutated aequorin was used for [Ca2+]M measurements. [Ca2+]c measurements were carried out using HeLa cells transiently transfected with the plasmid for cytosolic aequorin. | Positive | 234 | ||||
| kaempferol | 7μM | The HeLa cell clone MM5 expressing mitochondrially targeted mutated aequorin was used for [Ca2+]M measurements. [Ca2+]c measurements were carried out using HeLa cells transiently transfected with the plasmid for cytosolic aequorin. | Positive | EC50 | 234 | |||
| quercetin | 21 μM | mitochondrial Ca2+ uptake | Positive | EC50 | 234 | |||
| genistein | 37μM | mitochondrial Ca2+ uptake | Positive | EC50 | 234 | |||
| kaempferol | 10 μmol/L | periodically paced rat ventricular myocytes (VMs) under β-adrenergic stimulation | mitochondrial Ca2+ monitored by mitochondrial-targeted Ca2+ biosensor mtRCamp1h. | Positive | 241 | |||
| Ru360 | 2 μmol/L | Positive | 241 | |||||