T205 Source: Uniprot

proteinmCU (mitochondrial calcium uniporter) (MCU)
Ion channel
Full Name mCU (mitochondrial calcium uniporter)
Protein Names Calcium uniporter protein, mitochondrial, HsMCU (Coiled-coil domain-containing protein 109A)
Subcellular Location Mitochondrion inner membrane Multi-pass membrane protein
Uniprot Accession Q8NE86
Uniprot Name MCU_HUMAN
Gene symbol MCU
Gene Name Mitochondrial calcium uniporter
Ensembl ENSG00000156026

Compound Dose Time Species Model Method Result Positive criterion Reference
DS16570511 7 μM HEK293A cells HEK293A cell lines expressing the mitochondria-targeted Ca2+ indicator protein aequorin Positive IC50 302
SB202190 10 μM intact and in permeabilized HeLa cells (MM5 cells expressing mitmutAEQ ) mitochondrial Ca2+ uptake Positive 233
kaempferol 1μM The HeLa cell clone MM5 expressing mitochondrially targeted mutated aequorin was used for [Ca2+]M measurements. [Ca2+]c measurements were carried out using HeLa cells transiently transfected with the plasmid for cytosolic aequorin. Positive 234
kaempferol 7μM The HeLa cell clone MM5 expressing mitochondrially targeted mutated aequorin was used for [Ca2+]M measurements. [Ca2+]c measurements were carried out using HeLa cells transiently transfected with the plasmid for cytosolic aequorin. Positive EC50 234
quercetin 21 μM mitochondrial Ca2+ uptake Positive EC50 234
genistein 37μM mitochondrial Ca2+ uptake Positive EC50 234
kaempferol 10 μmol/L periodically paced rat ventricular myocytes (VMs) under β-adrenergic stimulation mitochondrial Ca2+ monitored by mitochondrial-targeted Ca2+ biosensor mtRCamp1h. Positive 241
Ru360 2 μmol/L Positive 241