T206 Source: Uniprot

proteinmitochondrial Na/Ca2+ exchanger (NCLX)
Ion channel
Full Name mitochondrial Na/Ca2+ exchanger
Protein Names Mitochondrial sodium/calcium exchanger protein (Na(+)/K(+)/Ca(2+)-exchange protein 6) (Sodium/calcium exchanger protein, mitochondrial) (Sodium/potassium/calcium exchanger 6) (Solute carrier family 24 member 6) (Solute carrier family 8 member B1)
Subcellular Location Mitochondrion inner membrane Multi-pass membrane protein
Uniprot Accession Q6J4K2
Uniprot Name NCLX_HUMAN
Gene symbol SLC8B1
Gene Name Solute carrier family 8 member B1
Ensembl ENSG00000089060

Compound Dose Time Species Model Method Result Positive criterion Reference
CGP37157 1 μmol/L Positive 241
CGP37157 1 μmol/L periodically paced rat ventricular myocytes (VMs) under β-adrenergic stimulation mitochondrial Ca2+ monitored by mitochondrial-targeted Ca2+ biosensor mtRCamp1h. Positive 241