T387002
| Compound | Dose | Time | Species | Model | Method | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Paraquat | 1 mM | 10 minutes | rat | isolated heart mitochondria | Measurement of hydrogen peroxide; Used glutamate/malate (5 mM) as substrate | Positive | 14 | |
| Paraquat | 1 mM | 10 minutes | rat | isolated heart mitochondria | Measurement of hydrogen peroxide; Used succinate (5 mM) as substrate | Positive | 14 | |
| Nimesulide | 0.5 mM | 20 minutes | rat; Sprague-Dawley Crl:CD (SD) BR | lung microsomes | horseadish preoxidase method (Green and Hill, 1984) | Positive | p < 0.05 | 11 |