Compound	Dose	Time	Species	Model	Method	Result	Positive criterion	Reference
Nimesulide	1 mM		rat; Sprague-Dawley Crl:CD (SD) BR	lung microsomes	adrenochrome assay (Misra and Fridovich, 1972)	Positive	p < 0.05	11
Nimesulide	0.5 mM	20 minutes	rat; Sprague-Dawley Crl:CD (SD) BR	lung microsomes	horseadish preoxidase method (Green and Hill, 1984)	Positive	p < 0.05	11
Zidovudine						Positive		307
Acyclovir						Positive		307
Ganciclovir						Positive		307
Zalcitabine						Positive		307
Sulindac						Positive		45
Ciprofloxacin						Positive		307
Cisplatin						Positive		307
Cyclophosphamide						Positive		307
Paraquat	10 mM		yeast; EG103 (Wild-type)	mitochondria	Measurement of superoxide anion	Negative		14
Paraquat	10 mM		yeast; EG103 (Wild-type)	mitochondria	Measurement of superoxide anion; Used ethanol (5 mM) as substrate	Negative		14
Paraquat	10 mM		yeast; EG110 (MnSOD knock-out)	mitochondria	Measurement of superoxide anion; Used ethanol (5 mM) as substrate	Positive		14
Paraquat	10 mM		yeast; EG103 (Wild-type)	mitochondria	Measurement of superoxide anion; Used ethanol (5 mM) as substrate	Positive		14
Paraquat	10 mM		yeast; EG103 (Wild-type)	mitochondria	Measurement of superoxide anion; Used ethanol (5 mM) as substrate; Used FCCP (1μm) as uncoupler	Negative		14
Paraquat	1 mM	10 minutes	rat	isolated heart mitochondria	Measurement of superoxide anion; Used glutamate/malate (5 mM) as substrate	Positive		14
Paraquat	1 mM	10 minutes	rat	isolated heart mitochondria	Measurement of superoxide anion; Used glutamate/malate (5 mM) as substrate; Used FCCP (1μm) as uncoupler	Negative		14
Paraquat	0.1 mM	10 minutes	rat	isolated heart mitochondria	Measurement of superoxide anion; Used succinate (5 mM) as substrate	Positive		14
Paraquat	1 mM	10 minutes	rat	isolated heart mitochondria	Measurement of superoxide anion; Used succinate (5 mM) as substrate; Used FCCP (1μm) as uncoupler	Negative		14
Paraquat	0.1 mM	10 minutes	rat	isolated heart mitochondria	Measurement of superoxide anion; Used succinate (5 mM) as substrate; Used rotenone (4μm) as inhibiter	Negative		14
Paraquat	1 mM	10 minutes	rat	isolated heart mitochondria	Measurement of hydrogen peroxide; Used glutamate/malate (5 mM) as substrate	Positive		14
Paraquat	1 mM	10 minutes	rat	isolated heart mitochondria	Measurement of hydrogen peroxide; Used succinate (5 mM) as substrate	Positive		14
Caffeine	> 100 µM	1 hour	Human	HepG2	High-content screening assay	Negative	MEC	306
citrate	> 100 µM	1 hour	Human	HepG2	High-content screening assay	Negative	MEC	306
Etoposide	> 100 µM	1 hour	Human	HepG2	High-content screening assay	Negative	MEC	306
Metformin	500 μM	24 hours	human	hepatocytes	ROS measurement	Negative		15
Metformin	1 mM	24 hours	human	hepatocytes	ROS measurement	Positive		15
Metformin	2 mM	24 hours	human	hepatocytes	ROS measurement	Positive		15
buformin	75 μM	24 hours	human	hepatocytes	ROS measurement	Positive		15
Phenformin	12.5 μM	24 hours	human	hepatocytes	ROS measurement	Positive		15
Rotenone	100 µM	1 hour	Human	HepG2	High-content screening assay	Positive	MEC	306
Amiodarone	10 µM	1 hour	Human	HepG2	High-content screening assay	Positive	MEC	306
Chlorpromazine	50 µM	1 hour	Human	HepG2	High-content screening assay	Positive	MEC	306
Cyclosporin A	5 µM	1 hour	Human	HepG2	High-content screening assay	Positive	MEC	306
imipramine	50 µM	1 hour	Human	HepG2	High-content screening assay	Positive	MEC	306
Maprotiline	5 µM	1 hour	Human	HepG2	High-content screening assay	Positive	MEC	306
Tamoxifen	5 µM	1 hour	Human	HepG2	High-content screening assay	Positive	MEC	306
Troglitazone	10 µM	1 hour	Human	HepG2	High-content screening assay	Positive	MEC	306
atorvastatin	100 µM	1 hour	Human	HepG2	High-content screening assay	Positive	MEC	306
Cerivastatin	5 µM	1 hour	Human	HepG2	High-content screening assay	Positive	MEC	306
fluvastatin	50 µM	1 hour	Human	HepG2	High-content screening assay	Positive	MEC	306
Acetylsalicylic acid	5 μmol/ml	24 hours	human	HepG2	ROS measurement	Negative	p < 0.05	2
Acetylsalicylic acid	5 μmol/ml	48 hours	human	HepG2	ROS measurement	Negative	p < 0.05	2
Acetylsalicylic acid	10 μmol/ml	24 hours	human	HepG2	ROS measurement	Positive	p < 0.05	2
Acetylsalicylic acid	10 μmol/ml	48 hours	human	HepG2	ROS measurement	Positive	p < 0.05	2
lovastatin	10 µM	1 hour	Human	HepG2	High-content screening assay	Positive	MEC	306
pravastatin	50 µM	1 hour	Human	HepG2	High-content screening assay	Positive	MEC	306
Simvastatin	5 µM	1 hour	Human	HepG2	High-content screening assay	Positive	MEC	306

T387001. superoxide
T387002. hydrogen peroxide

F05. Oxidative stress
F0504. ROS production