GO:0005757
Transmembrane potential >> Permeabilization >> Opening of permeability transition pore (PTP)

Related Drugs/Compounds

Compound	Dose	Time	Species	Model	Method	Action	Result	Positive criterion	Reference
Troglitazone	10–75 μM		male CD-1 mice	isolated liver mitochondria	Mitochondrial swelling as the indicator of mitochondrial permeability transition (MPT) was estimated from the decrease in absorbance at 540 nm.	induce	Positive		331
Ciglitazone	10–75 μM		male CD-1 mice	isolated liver mitochondria	Mitochondrial swelling as the indicator of mitochondrial permeability transition (MPT) was estimated from the decrease in absorbance at 540 nm.	induce	Positive		331
Cyclosporin A						inhibit	Positive		248
Troglitazone	10 µM	6hr	ZDF fa/fa rat vs ZDF lean rat	hepatocytes	Co2+-calcein assays; MPT pore opening was determined by measuring intensity of calcein fluorescence in the mitochondria quenched by cobalt and normalizing cell number of hoechst33342.	induce	Positive	significantly different from ZDF lean rats (p < 0.05)	225
Sulindac						increase	Positive		45
Troglitazone						increase	Positive		7
Chlorpromazine	>100 µM	1 hour	Human	HepG2	High-content screening assay	Affect	Positive	MEC	306
Thioridazine						increase	Positive		49
JW47	10nM		rat	liver mitochondria	Assess Ca2+-mediated PT pore formation by Calcium Retention Capacity Assay (Fluo-5N fluorescence was measured in the extramitochondrial solution following repeated additions of Ca2+)	inhibit	Positive	half-maximal inhibition	324
Cyclosporin A	40nM		rat	liver mitochondria	Assess Ca2+-mediated PT pore formation by Calcium Retention Capacity Assay (Fluo-5N fluorescence was measured in the extramitochondrial solution following repeated additions of Ca2+)	inhibit	Positive	half-maximal inhibition	324
Nimesulide							Positive		197
Berberine	31.2 nmol/mg			isolated rat muscle mitochondria	evaluate mitochondrial calcium loading capacity using the fluorescence probe Calcium Green 5N	induce	Positive		327
Cinnamic anilides					swellilng assay, Rhodamine 123 (Rh123) uptake assay, Calcium retention capacity assay	induce	Positive		290
chenodeoxycholic acid			rat	isolated liver mitochondria		increase	Positive		55
Bupivacaine						decrease	Positive		61
Amiodarone	10 µM	1 hour	Human	HepG2	High-content screening assay	Increase	Positive	MEC	306
imipramine	50 µM	1 hour	Human	HepG2	High-content screening assay	Decrease	Positive	MEC	306
Maprotiline	5 µM	1 hour	Human	HepG2	High-content screening assay	Decrease	Positive	MEC	306
Rotenone	5 µM	1 hour	Human	HepG2	High-content screening assay	Decrease	Positive	MEC	306
aristolochic acid				isolated kidney mitochondria		increase	Positive		64
Tamoxifen	100 µM	1 hour	Human	HepG2	High-content screening assay	Decrease	Positive	MEC	306
Troglitazone	5 µM	1 hour	Human	HepG2	High-content screening assay	Decrease	Positive	MEC	306
atorvastatin	50 µM	1 hour	Human	HepG2	High-content screening assay	Decrease	Positive	MEC	306
Cerivastatin	10 µM	1 hour	Human	HepG2	High-content screening assay	Decrease	Positive	MEC	306
fluvastatin	10 µM	1 hour	Human	HepG2	High-content screening assay	Decrease	Positive	MEC	306
lovastatin	50 µM	1 hour	Human	HepG2	High-content screening assay	Decrease	Positive	MEC	306
Menadione						increase	Positive		35
Simvastatin	10 µM	1 hour	Human	HepG2	High-content screening assay	Decrease	Positive	MEC	306
Troglitazone	10 µM	6hr	type 2 diabetes mellitus model rat	primary hepatocytes or isolated mitochondria	The loss of mitochondrial calcein and Hoechst 33342 nuclear fluorescence using a fluorescence microscope as an indicator of MPT for rat primary hepatocyte . Mitochondrial swelling as an indicator of MPT for isolated mitochondria.		Positive		225
Troglitazone						increase	Positive		35