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F02010104 | State 4 respiration


Function of mitochondria >> Respiration >> Respiratory states >> state 4 respiration

Compound Dose Time Species Model Method Action Result Positive criterion Reference
Perhexiline 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake increase Positive p < 0.01 193
imipramine increase Positive 22
nitrofurazone 5μM mouse; C57B/6J mitoplasts Measurement of oxygen uptake decrease Positive p < 0.05 13
clomipramine increase Positive 22
promethazine increase Positive 22
Perhexiline 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake increase Positive p < 0.01 193
Metformin 2mM 30 minutes mouse; C57BL/6J isolated skeletal muscle mitochondria Measurement of Oxygen level; incubated in complex I substrate; added oligomycin (2.5 μg oligomycin/mg mitochondrial protein) decrease Positive p < 0.05 172
Perhexiline 100 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake increase Positive p < 0.01 193
Perhexiline 100 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake increase Positive p < 0.01 193
Chlorpromazine increase Positive 22