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F02040103 | Lactate production

GO:0019659 map00010 R-HSA-70171
Function of mitochondria >> Glucose metabolism >> Glycolysis >> lactate production

Compound Dose Time Species Model Method Action Result Positive criterion Reference
Metformin 5 mM 24 hours mouse NT2196 Meassurement of lactate concentration increase Positive p < 0.05 172
Metformin 5 mM 24 hours human MCF10A Meassurement of lactate concentration increase Positive p < 0.05 172
Metformin 5 mM 24 hours human MCF7 Meassurement of lactate concentration increase Positive p < 0.05 172
Metformin 5 mM 48 hours mouse NMuMG Meassurement of lactate concentration increase Positive p < 0.05 172
Metformin 5 mM 48 hours mouse NT2196 Meassurement of lactate concentration increase Positive p < 0.05 172
Metformin 5 mM 48 hours human MCF10A Meassurement of lactate concentration increase Positive p < 0.05 172
Metformin 5 mM 48 hours human MCF7 Meassurement of lactate concentration increase Positive p < 0.05 172