Compound	Dose	Time	Species	Model	Method	Action	Result	Positive criterion	Reference
Emtricitabine							Positive		194
Zidovudine						increase	Positive		307
Acyclovir						increase	Positive		307
Ganciclovir						increase	Positive		307
Zalcitabine						increase	Positive		307
Zidovudine						decrease	Positive		307
Acyclovir						decrease	Positive		307
Ganciclovir						decrease	Positive		307
Zalcitabine						decrease	Positive		307
Linezolid	16 ± 2 μM			Isolated rat heart mitochondria	Mitochondrial protein synthesis (MPS) assay with [35S]methionine		Positive	IC50	282
eperezolid	9.5 ± 1.5 μM			Isolated rat heart mitochondria	Mitochondrial protein synthesis (MPS) assay with [35S]methionine		Positive	IC50	282
eperezolid	4.2 ± 0.4 μM		rat	Isolated liver mitochondria	Mitochondrial protein synthesis assay (The incorporation of [35S]methionine into mitochondrial protein was determined by a filter paper disk assay )		Positive	IC50	281
Chloramphenicol	9.8 ± 0.5 μM		rat	liver mitochondria	Mitochondrial protein synthesis assay (The incorporation of [35S]methionine into mitochondrial protein was determined by a filter paper disk assay )		Positive	IC50	281
tetracyclines	2.1 ± 0.5 μM		rat	liver mitochondria	Mitochondrial protein synthesis assay (The incorporation of [35S]methionine into mitochondrial protein was determined by a filter paper disk assay )		Positive	IC50	281
Linezolid	12.8 ± 2.8 μM		rat	liver mitochondria	Mitochondrial protein synthesis assay (The incorporation of [35S]methionine into mitochondrial protein was determined by a filter paper disk assay )		Positive	IC50	281
Abacavir							Positive		185
tetracyclines						decrease	Positive		307
Ciprofloxacin						decrease	Positive		307
Ciprofloxacin						decrease	Positive		307
LDC203974	0–10 μM				Single nucleotide incorporation assays at varying ATP concentrations	inhibit	Positive	Vmax app, maximum reaction rate; Km app, substrate affinity	314
Cisplatin						Increase	Positive		307
Cyclophosphamide						Increase	Positive		307
LDC203974	743nM				Microscale thermophoresis binding curves in the absence or presence of 10 μM IMT1B	inhibit	Positive	Kd	314
LDC203974	10 μM	6hr		HeLa cells	Mitochondrial transcript levels of ND1 and CYTB	inhibit	Positive		314
Paraquat	100 μM	48 hours	yeast; EG110 (MnSOD knock-out)	mitochondria	Measurement of Mitochondrial DNA point mutations	increase	Positive	p < 0.01	14
doxycycline				143B osteosarcoma cells		inhibitor	Positive		285
Chloramphenicol					haplo-insufficiency profiling (HIP), a well-validated chemical genomics platform developed in the yeast S. Cerevisiae.	inhibitor	Positive		288
Linezolid					haplo-insufficiency profiling (HIP), a well-validated chemical genomics platform developed in the yeast S. Cerevisiae.	inhibitor	Positive		288
Linezolid							Positive		197
tigecycline					haplo-insufficiency profiling (HIP), a well-validated chemical genomics platform developed in the yeast S. Cerevisiae.	inhibitor	Positive		288
tigecycline	2.5-10μM	48hr		TEX, OCI-AML2, and two AML patients' cells	weatern blot (protein levels of Cox-1, Cox-2, Cox-4, Grp78, XIAP, Actin, and tubulin)	inhibitor	Positive		288
Menadione	6.0 μM	1 hours	human	pFastBac	Meassurement of DNA polymerase gamma activity	affect	Positive	IC50	9
Stavudine						depletion	Positive		197
Simvastatin						depletion	Positive		197
Dequalinium Chloride		24 hr		Caco-2 and Ishikawa cells	Relative quantification of mtDNA copy number was measured using the QuantiTect SYBR Green PCR kit	decrease	Positive		299
Cisplatin		24 hr		Caco-2 and Ishikawa cells	Relative quantification of mtDNA copy number was measured using the QuantiTect SYBR Green PCR kit	decrease	Positive		299
Troglitazone			human	hepatocytes	Assay for mtDNA damage: MtDNA damage was assessed as the diminished intensity in the 16.5 kb restriction band, as compared to control bands.	damage	Positive		226
Zalcitabine							Positive		194
Didanosine							Positive		194
Stavudine							Positive		194
Lamivudine							Positive		194
Tenofovir							Positive		194
Zidovudine							Positive		194
Carbovir							Positive		194
Abacavir							Positive		194
Fialuridine							Positive		194

F0601. Mitochondrial DNA maintainance
F0602. Mitochondrial DNA mutation
F0603. mitochondrial RNA processing
F0604. mitochondrial protein translation
F0605. Mitochondrial DNA damage
F060101. mitochondrial DNA metabolic process
F060102. mitochondrial DNA metabolic process
F060103. mitochondrial DNA metabolic process
F060104. mitochondrial DNA metabolic process
F060105. mitochondrial DNA metabolic process
F060301. mitochondrial transcription
F060302. mitochondrial mRNA processing
F060303. mitochondrial tRNA processing
F060304. mitochondrial rRNA processing
F060401. mitochondrial translational elongation

T231. DNA-directed RNA polymerase, mitochondrial
T234. DNA polymerase gamma
T320. 39S ribosomal protein L3, mitochondrial