F0601 | Mitochondrial DNA maintainance

GO:0000002 F0601
Mitochondrial DNA >> Mitochondrial DNA maintainance

Compound Dose Time Species Model Method Action Result Positive criterion Reference
Emtricitabine Positive 194
Zidovudine increase Positive 307
Acyclovir increase Positive 307
Ganciclovir increase Positive 307
Zalcitabine increase Positive 307
Abacavir Positive 185
Ciprofloxacin decrease Positive 307
Ciprofloxacin decrease Positive 307
Menadione 6.0 μM 1 hours human pFastBac Meassurement of DNA polymerase gamma activity affect Positive IC50 9
Dequalinium Chloride 24 hr Caco-2 and Ishikawa cells Relative quantification of mtDNA copy number was measured using the QuantiTect SYBR Green PCR kit decrease Positive 299
Cisplatin 24 hr Caco-2 and Ishikawa cells Relative quantification of mtDNA copy number was measured using the QuantiTect SYBR Green PCR kit decrease Positive 299
Zalcitabine Positive 194
Didanosine Positive 194
Stavudine Positive 194
Lamivudine Positive 194
Tenofovir Positive 194
Zidovudine Positive 194
Carbovir Positive 194
Abacavir Positive 194
Fialuridine Positive 194