F06 | Mitochondrial DNA

GO:0140053
Mitochondrial DNA

Compound Dose Time Species Model Method Action Result Positive criterion Reference
Emtricitabine Positive 194
Zidovudine increase Positive 307
Acyclovir increase Positive 307
Ganciclovir increase Positive 307
Zalcitabine increase Positive 307
Zidovudine decrease Positive 307
Acyclovir decrease Positive 307
Ganciclovir decrease Positive 307
Zalcitabine decrease Positive 307
Linezolid 16 ± 2 μM Isolated rat heart mitochondria Mitochondrial protein synthesis (MPS) assay with [35S]methionine Positive IC50 282
eperezolid 9.5 ± 1.5 μM Isolated rat heart mitochondria Mitochondrial protein synthesis (MPS) assay with [35S]methionine Positive IC50 282
eperezolid 4.2 ± 0.4 μM rat Isolated liver mitochondria Mitochondrial protein synthesis assay (The incorporation of [35S]methionine into mitochondrial protein was determined by a filter paper disk assay ) Positive IC50 281
Chloramphenicol 9.8 ± 0.5 μM rat liver mitochondria Mitochondrial protein synthesis assay (The incorporation of [35S]methionine into mitochondrial protein was determined by a filter paper disk assay ) Positive IC50 281
tetracyclines 2.1 ± 0.5 μM rat liver mitochondria Mitochondrial protein synthesis assay (The incorporation of [35S]methionine into mitochondrial protein was determined by a filter paper disk assay ) Positive IC50 281
Linezolid 12.8 ± 2.8 μM rat liver mitochondria Mitochondrial protein synthesis assay (The incorporation of [35S]methionine into mitochondrial protein was determined by a filter paper disk assay ) Positive IC50 281
Abacavir Positive 185
tetracyclines decrease Positive 307
Ciprofloxacin decrease Positive 307
Ciprofloxacin decrease Positive 307
LDC203974 0–10 μM Single nucleotide incorporation assays at varying ATP concentrations inhibit Positive Vmax app, maximum reaction rate; Km app, substrate affinity 314
Cisplatin Increase Positive 307
Cyclophosphamide Increase Positive 307
LDC203974 743nM Microscale thermophoresis binding curves in the absence or presence of 10 μM IMT1B inhibit Positive Kd 314
LDC203974 10 μM 6hr HeLa cells Mitochondrial transcript levels of ND1 and CYTB inhibit Positive 314
Paraquat 100 μM 48 hours yeast; EG110 (MnSOD knock-out) mitochondria Measurement of Mitochondrial DNA point mutations increase Positive p < 0.01 14
doxycycline 143B osteosarcoma cells inhibitor Positive 285
Chloramphenicol haplo-insufficiency profiling (HIP), a well-validated chemical genomics platform developed in the yeast S. Cerevisiae. inhibitor Positive 288
Linezolid haplo-insufficiency profiling (HIP), a well-validated chemical genomics platform developed in the yeast S. Cerevisiae. inhibitor Positive 288
Linezolid Positive 197
tigecycline haplo-insufficiency profiling (HIP), a well-validated chemical genomics platform developed in the yeast S. Cerevisiae. inhibitor Positive 288
tigecycline 2.5-10μM 48hr TEX, OCI-AML2, and two AML patients' cells weatern blot (protein levels of Cox-1, Cox-2, Cox-4, Grp78, XIAP, Actin, and tubulin) inhibitor Positive 288
Menadione 6.0 μM 1 hours human pFastBac Meassurement of DNA polymerase gamma activity affect Positive IC50 9
Stavudine depletion Positive 197
Simvastatin depletion Positive 197
Dequalinium Chloride 24 hr Caco-2 and Ishikawa cells Relative quantification of mtDNA copy number was measured using the QuantiTect SYBR Green PCR kit decrease Positive 299
Cisplatin 24 hr Caco-2 and Ishikawa cells Relative quantification of mtDNA copy number was measured using the QuantiTect SYBR Green PCR kit decrease Positive 299
Troglitazone human hepatocytes Assay for mtDNA damage: MtDNA damage was assessed as the diminished intensity in the 16.5 kb restriction band, as compared to control bands. damage Positive 226
Zalcitabine Positive 194
Didanosine Positive 194
Stavudine Positive 194
Lamivudine Positive 194
Tenofovir Positive 194
Zidovudine Positive 194
Carbovir Positive 194
Abacavir Positive 194
Fialuridine Positive 194