Compound	Dose	Time	Species	Model	Method	Result	Positive criterion	Reference
Metformin	62.5 μM	24 hours	human	HepG2 cells	Assay of Cellular ATP Content	Negative	p < 0.001	15
Metformin	62.5 μM	24 hours	human	HepG2 cells	Assay of Cellular ATP Content	Negative	p < 0.001	15
buformin	62.5 μM	24 hours	human	HepG2 cells	Assay of Cellular ATP Content	Positive	p < 0.001	15
buformin	62.5 μM	24 hours	human	HepG2 cells	Assay of Cellular ATP Content	Positive	p < 0.001	15
Phenformin	62.5 μM	24 hours	human	HepG2 cells	Assay of Cellular ATP Content	Positive	p < 0.001	15
Phenformin	62.5 μM	24 hours	human	HepG2 cells	Assay of Cellular ATP Content	Positive	p < 0.001	15
Metformin	657 μM	24 hours	human	hepatocytes	Assay of Cellular ATP Content	Positive	IC50	15
buformin	26.1 μM	24 hours	human	hepatocytes	Assay of Cellular ATP Content	Positive	IC50	15
Phenformin	11.7 μM	24 hours	human	hepatocytes	Assay of Cellular ATP Content	Positive	IC50	15
Metformin	1430 μM	24 hours	human	HepG2 cells	Assay of Cellular ATP Content	Positive	IC50	15
buformin	43.7 μM	24 hours	human	HepG2 cells	Assay of Cellular ATP Content	Positive	IC50	15
Phenformin	12.9 μM	24 hours	human	HepG2 cells	Assay of Cellular ATP Content	Positive	IC50	15
Metformin	> 2000 μM	24 hours	human	HepG2 cells	Assay of Cellular ATP Content	Positive	IC50	15
buformin	> 500 μM	24 hours	human	HepG2 cells	Assay of Cellular ATP Content	Positive	IC50	15
Phenformin	> 500 μM	24 hours	human	HepG2 cells	Assay of Cellular ATP Content	Positive	IC50	15
Diclofenac	250 μmol/L	24 hours	rat	hepatocytes	Assay of Cellular ATP contents; Assay of LDH leakage	Positive	p < 0.01	6
Diclofenac	500 μmol/L	24 hours	rat	hepatocytes	Assay of Cellular ATP contents; Assay of LDH leakage	Positive	p < 0.01	6

F021201. ATP synthesis
F020103. electron transport chain