| Etomoxir |
|
|
|
|
|
Positive |
|
35 |
| Perhexiline |
|
|
|
|
|
Positive |
|
16 |
| Perhexiline |
|
|
|
|
|
Positive |
|
17 |
| aminocarnitine |
76.4/27.3 |
|
human/rat |
recombinant Pichia pastoris Membrane Preparations |
spectrophotometric assay with DTNB |
Positive |
IC50 (μM) |
333 |
| palmitoylaminocarnitine |
2.67/− |
|
human/rat |
recombinant Pichia pastoris Membrane Preparations |
spectrophotometric assay with DTNB |
Positive |
IC50 (μM) |
333 |
| ST1326 |
1.05/1.45 |
|
human/rat |
recombinant Pichia pastoris Membrane Preparations |
spectrophotometric assay with DTNB |
Positive |
IC50 (μM) |
333 |
| ST2425 |
1.70/− |
|
human/rat |
recombinant Pichia pastoris Membrane Preparations |
spectrophotometric assay with DTNB |
Positive |
IC50 (μM) |
333 |
| Trimetazidine |
>100/− |
|
human/rat |
recombinant Pichia pastoris Membrane Preparations |
spectrophotometric assay with DTNB |
Negative |
IC50 (μM) |
333 |
| Perhexiline |
>100/− |
|
human/rat |
recombinant Pichia pastoris Membrane Preparations |
spectrophotometric assay with DTNB |
Negative |
IC50 (μM) |
333 |
| Amiodarone |
>100/− |
|
human/rat |
recombinant Pichia pastoris Membrane Preparations |
spectrophotometric assay with DTNB |
Negative |
IC50 (μM) |
333 |
| Oxfenicine |
>100/− |
|
human/rat |
recombinant Pichia pastoris Membrane Preparations |
spectrophotometric assay with DTNB |
Negative |
IC50 (μM) |
333 |
| oxfenicine metabolite |
>100/− |
|
human/rat |
recombinant Pichia pastoris Membrane Preparations |
spectrophotometric assay with DTNB |
Negative |
IC50 (μM) |
333 |
| RO-25-0187 |
2.4/− |
|
human/rat |
recombinant Pichia pastoris Membrane Preparations |
spectrophotometric assay with DTNB |
Positive |
IC50 (μM) |
333 |
| aminocarnitine |
>100 |
|
human/rat |
recombinant Pichia pastoris Membrane Preparations |
spectrophotometric assay with DTNB |
Negative |
IC50 (μM) |
333 |
| palmitoylaminocarnitine |
21.7 |
|
human/rat |
recombinant Pichia pastoris Membrane Preparations |
spectrophotometric assay with DTNB |
Positive |
IC50 (μM) |
333 |
| ST1326 |
5.4 |
|
human/rat |
recombinant Pichia pastoris Membrane Preparations |
spectrophotometric assay with DTNB |
Positive |
IC50 (μM) |
333 |
| ST2425 |
85.3 |
|
human/rat |
recombinant Pichia pastoris Membrane Preparations |
spectrophotometric assay with DTNB |
Positive |
IC50 (μM) |
333 |
| Trimetazidine |
>100 |
|
human/rat |
recombinant Pichia pastoris Membrane Preparations |
spectrophotometric assay with DTNB |
Negative |
IC50 (μM) |
333 |
| Perhexiline |
>100 |
|
human/rat |
recombinant Pichia pastoris Membrane Preparations |
spectrophotometric assay with DTNB |
Negative |
IC50 (μM) |
333 |
| Amiodarone |
>100 |
|
human/rat |
recombinant Pichia pastoris Membrane Preparations |
spectrophotometric assay with DTNB |
Negative |
IC50 (μM) |
333 |
| Oxfenicine |
>100 |
|
human/rat |
recombinant Pichia pastoris Membrane Preparations |
spectrophotometric assay with DTNB |
Negative |
IC50 (μM) |
333 |
| oxfenicine metabolite |
60.3 |
|
human/rat |
recombinant Pichia pastoris Membrane Preparations |
spectrophotometric assay with DTNB |
Positive |
IC50 (μM) |
333 |
| RO-25-0187 |
0.16 |
|
human/rat |
recombinant Pichia pastoris Membrane Preparations |
spectrophotometric assay with DTNB |
Positive |
IC50 (μM) |
333 |
| Valproic Acid |
|
|
|
|
|
Positive |
|
227 |
| Amiodarone |
|
|
|
|
|
Positive |
|
227 |
| Perhexiline |
|
|
|
|
|
Positive |
|
35 |
| Tamoxifen |
|
|
|
|
|
Positive |
|
227 |
| Tamoxifen |
|
|
|
|
|
Positive |
|
227 |
| Etomoxir |
5 μM |
|
|
T cell |
|
Positive |
|
257 |
| Perhexiline |
77 μmol/L |
|
rat |
cardiac mitochondria |
CPT-1 activity was measured by the formation of palmitoyl-[3H]-carnitine from palmitoyl-CoA and [3H]-I- carnitine, |
Positive |
IC50 |
240 |
| Perhexiline |
148 μmol/L |
|
rat |
hepatic mitochondria |
CPT-1 activity was measured by the formation of palmitoyl-[3H]-carnitine from palmitoyl-CoA and [3H]-I- carnitine, |
Positive |
IC50 |
240 |
| Amiodarone |
228 μmol/L |
|
rat |
cardiac and hepatic mitochondria |
CPT-1 activity was measured by the formation of palmitoyl-[3H]-carnitine from palmitoyl-CoA and [3H]-I- carnitine, |
Positive |
IC50 |
240 |
