T021001 Source: Uniprot
protein subunitCarnitine O-palmitoyltransferase 1, liver isoform, CPT1-L, EC 2.3.1.21
(CPT-1A)
Transferase
Acyltransferase
carnitine palmitoyltransferases I >>
| Full Name | Carnitine O-palmitoyltransferase 1, liver isoform, CPT1-L, EC 2.3.1.21 |
|---|---|
| Protein Names | Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A) |
| Subcellular Location | Mitochondrion outer membrane Multi-pass membrane protein |
| EC numbers | 2.3.1.21 |
| Uniprot Accession | P50416 |
| Uniprot Name | CPT1A_HUMAN |
| Gene symbol | CPT1A |
| Gene Name | Carnitine palmitoyltransferase 1A |
| Ensembl | ENSG00000110090 |
| Compound | Dose | Time | Species | Model | Method | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| aminocarnitine | 76.4/27.3 | human/rat | recombinant Pichia pastoris Membrane Preparations | spectrophotometric assay with DTNB | Positive | IC50 (μM) | 333 | |
| palmitoylaminocarnitine | 2.67/− | human/rat | recombinant Pichia pastoris Membrane Preparations | spectrophotometric assay with DTNB | Positive | IC50 (μM) | 333 | |
| ST1326 | 1.05/1.45 | human/rat | recombinant Pichia pastoris Membrane Preparations | spectrophotometric assay with DTNB | Positive | IC50 (μM) | 333 | |
| ST2425 | 1.70/− | human/rat | recombinant Pichia pastoris Membrane Preparations | spectrophotometric assay with DTNB | Positive | IC50 (μM) | 333 | |
| Trimetazidine | >100/− | human/rat | recombinant Pichia pastoris Membrane Preparations | spectrophotometric assay with DTNB | Negative | IC50 (μM) | 333 | |
| Perhexiline | >100/− | human/rat | recombinant Pichia pastoris Membrane Preparations | spectrophotometric assay with DTNB | Negative | IC50 (μM) | 333 | |
| Amiodarone | >100/− | human/rat | recombinant Pichia pastoris Membrane Preparations | spectrophotometric assay with DTNB | Negative | IC50 (μM) | 333 | |
| Oxfenicine | >100/− | human/rat | recombinant Pichia pastoris Membrane Preparations | spectrophotometric assay with DTNB | Negative | IC50 (μM) | 333 | |
| oxfenicine metabolite | >100/− | human/rat | recombinant Pichia pastoris Membrane Preparations | spectrophotometric assay with DTNB | Negative | IC50 (μM) | 333 | |
| RO-25-0187 | 2.4/− | human/rat | recombinant Pichia pastoris Membrane Preparations | spectrophotometric assay with DTNB | Positive | IC50 (μM) | 333 | |
| Etomoxir | 5 μM | T cell | Positive | 257 | ||||