T416 Source: Uniprot
enzymeSerine/threonine-protein kinase mTOR
(mTOR)
Transferase
Serine/threonine-protein kinase
Kinase
| Full Name | Serine/threonine-protein kinase mTOR |
|---|---|
| Protein Names | Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) |
| Subcellular Location | Cytoplasm Cytoplasmic side Endoplasmic reticulum membrane Golgi apparatus membrane Lysosome Lysosome membrane Microsome membrane Mitochondrion outer membrane Nucleus, PML body Peripheral membrane protein |
| EC numbers | 2.7.11.1 |
| Uniprot Accession | P42345 |
| Uniprot Name | MTOR_HUMAN |
| Gene symbol | MTOR |
| Gene Name | Mechanistic target of rapamycin kinase |
| Ensembl | ENSG00000198793 |
| Compound | Dose | Time | Species | Model | Method | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| rapamycin | 200 nM | Positive | 252 | |||||
| Bafilomycin A1 | Positive | 200 | ||||||
| everolimus | Positive | 266 | ||||||
| rapamycin | mouse | embryonic retinas | Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye | Positive | 252 | |||