Compound	Dose	Time	Species	Model	Method	Action	Result	Positive criterion	Reference
sertraline						Change	Positive		307
Fluoxetine						Change	Positive		307
Clozapine							Positive		197
Troglitazone	25 µM			HepG2 cells	Images from transmission electron microscopy	abnormal	Positive		332
MG-132	20 μM	6 hr		HeLa cells	The cells were stained with MitoTracker Green FM and MitoSOX Red dyes followed by image acquisition on a confocal microscope.	induce	Positive		291
Hydrazine	2 mM	22-24 h		primary culture rat hepatocytes, RL-34(JCRB 0247), COS-1(JCRB 9082) IAR-20(JCRB 0610)		induce	Positive		292
H2O2	0.2mM	22hr		rimary culture rat hepatocytes, RL-34,COS-1, IAR-20		induce	Positive		292
Chloramphenicol	200-300µg/ml	22hr		primary culture rat hepatocytes, RL-34,COS-1, IAR-20		induce	Positive		292
Ethidium Bromide	200-300 µg/ml, 2	22h		RL-34, COS-1, IAR-20L cells (mouse fibrob-lasts)		induce	Positive		292
Erythromycin	200 µg/ml	22 h		primary culture rat hepatocytes, RL-34,COS-1, IAR-20		induce	Positive		292
Indomethacin	0.3-0.5 mM	22 h		primary culture rat hep-atocytes, RL-34,COS-1, IAR-20		induce	Positive		292
Cisplatin							Positive		197
Ethanol	12.5-500 mM	5min	rat	cardiac myocytes		induce	Positive		292
Niclosamide	1, 5, and 10 uM	3 hr (1.5-6hr)		HeLa/mito-YFP	fluorescence microscope	induce	Positive		294
Ethanol	1-3%	6hr		RL-34		induce	Positive		292
Diazepam	140μg/ml	16hr		PE cells	Energy-dependent accumulation of ethylrhodamine ; Electron micrographs of ultrathin sections	induce	Positive		293
P110	1 µM	30min		Cultured SH-SY5Y cells incubated with MPP+ (2 mM, for 4 hours) or CCCP (5 µM, for 30 minutes). The cells were then stained with anti-Tom20 antibody (green) and Hoechst stain.	microscopy images	inhibit	Positive		310
tacrolimus				beta cells from isolated rat islets	Transmission electron microscopy and 3D reconstruction of mitochondria	decrease	Positive		322
BGP-15	50 μM	4hr		WRL-68 cells	mERFP-labeled WRL-68 cells	reduce	Positive		297
H2O2	10 μmol/10E7 cells	4-6hr	C2C12 mouse	muscle myoblasts	detected by either MitoTracker Red staining, or by mERFP transfection	induce	Positive		297

F030601. volume
F030602. formation and maintenance of cristae structure
F030603. fragmentation
F030604. megamitochondria

T358. Dynamin-1-like protein