Compound	Dose	Time	Species	Model	Method	Action	Result	Positive criterion	Reference
Mdivi-1						inhibitor	Positive		296
Zidovudine						abnormalize	Positive		307
Acyclovir						abnormalize	Positive		307
Ganciclovir						abnormalize	Positive		307
Zalcitabine						abnormalize	Positive		307
XCT790						inhibit	Positive		308
P110	1 µM	30min		Cultured SH-SY5Y cells incubated with MPP+ (2 mM, for 4 hours) or CCCP (5 µM, for 30 minutes). The cells were then stained with anti-Tom20 antibody (green) and Hoechst stain.	microscopy images	inhibit	Positive		310
colchicine							Positive		185
docetaxel							Positive		185
Saquinavir						decrease	Positive		307
Rosiglitazone		1, 2, 4, 7, 24, and 48 hrs	Murine	differentiated 3T3-L1 and C3H/10T1/2 adipocytes		increase	Positive		179
Rosiglitazone	1uM	24 and 48 hours	Murine	adipocytes	Mitochondrial Staining and Quantification	affect	Positive		179
Clozapine						Increase	Positive		307
sertraline						decrease	Positive		307
Fluoxetine						decrease	Positive		307
sertraline						Change	Positive		307
Fluoxetine						Change	Positive		307
Berberine				isolated rat muscle mitochondria	decrease of absorbance at 540 nm with a Jasco V-560 spectrophotometer	increase	Positive		327
Acetaminophen	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Acetylsalicylic acid	> 800 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Amantadine	> 800 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Ambroxol	> 400 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Amoxicillin	> 400 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Ampicillin	> 400 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Antipyrine	> 400 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Arsenic trioxide	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Biotin	5.6 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
lumiracoxib	> 400 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
bisacodyl	> 400 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Bupivacaine	> 800 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Busulfan	> 800 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Butein	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Caffeine	> 400 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Capsaicin	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Carbamazepine	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Cefixime	> 400 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Chlorambucil	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Ciprofloxacin	> 400 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Clodronate	> 400 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
curcumin	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Daunorubicin	< 6.25 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
dexamethasone valerate	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Diazoxide	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Diclofenac	> 800 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Diflunisal	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Doxorubicin	85 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Fluconazole	> 400 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Flufenamic Acid	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Flutamide	> 800 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
gefitinib	63.6 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
genistein	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Gossypol	> 10 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Ibuprofen	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
imipramine	274.4 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Indomethacin	> 800 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Isoniazid	> 800 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Ketoconazole	> 400 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Lamivudine	> 400 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Lidocaine	> 800 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Lonidamine	660 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
lovastatin	71.5 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
lumiracoxib	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Manganese	> 800 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Mefenamic acid	> 400 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Metformin	> 400 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Nicotine	> 400 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
nifuroxazide	> 400 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Nimesulide	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Nitrofurantoin	> 800 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Perhexiline	14.8 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Piroxicam	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
pravastatin	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
propylparaben	> 800 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Pyrazinamide	> 400 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
resveratrol	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
riboflavin	672.3 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
rifampicin	> 800 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Salicylic acid	> 400 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Simvastatin	173.2 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Sulindac	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Tamoxifen	9 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Tolcapone	> 400 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Tolfenamic Acid	> 800 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Troglitazone	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Valproic Acid	> 800 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Zidovudine	> 200 µM	30 mins	mouse	liver mitochondria	swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )	increase	Positive	EC20	36
Amiodarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurements of mitochondrial swelling	increase	Positive	p < 0.05	4
benzarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurements of mitochondrial swelling	increase	Positive	p < 0.05	4
benzbromarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurements of mitochondrial swelling	increase	Positive	p < 0.05	4
Clozapine							Positive		197
Etoposide				isolated mitochondria		increase	Positive		57
Cisplatin							Positive		197
Chlorpyrifos	30 μM		Human	Human induced pluripotent stem cells (iPSCs)		increase	Positive		242
Paraquat						increase	Positive		67
Mdivi-1							Positive		248
Urolithin A						enhance	Positive		248
Ozone	1 μg O 3/mL			HeLa cells			Positive		247
Ozone	10 μg O 3/mL			HeLa cells			Positive		247
Nicotine	10 mM		Human	Human embryonal carcinoma cells (NT2/D1)			Positive		247
Cisplatin	3 mg/kg bodyweight	twice a week for 2 weeks	Mouse	Mouse tibial nerves and dorsal root ganglia (L1–L4)			Positive		247
Doxorubicin	7.2 μM DXR for 24 hrs		Human	fibroblasts			Positive		247
MDMA	20 μM MDMA mixture for 24 hrs			Mouse primary hippocampal neurons			Positive		247
Metamfetamine	0.5, 1, 2 mM Meth for 24 hrs			Human neuroblastoma SH- SY5Y			Positive		247
Troglitazone	10 µM		ZDF fa/fa rat vs ZDF lean rat	isolated liver mitochondria	Mitochondrial swelling as an indicator of MPT was determined by the decrease in absorbance at 540 nm on a UV-2550 spectrophotometer.	induce	Positive	significantly different from ZDF lean rats (p < 0.05)	225
Perfluorooctanoic acid	In utero exposure (GD 1–17) to 1 mg/kg bodyweight dam			Post-natal day 91 mouse livers			Positive		247
Cadmium	In vitro: 12uM CdCl2 In vivo: 2mg/kg CdCl2			Rat hepatocytes			Positive		247
Manganese	Infusion of 1 μM MnCl2			Rat glia			Positive		247
Methylmercury	20 μM			Human HepG2 cells			Positive		247
Chlorpyrifos	30 μM			Human stem cell-derived neural progenitor cells			Positive		247
2,4-dinitrophenol	50 μM DNP at 3 hours post fertilization (hpf)			Danio rerio			Positive		247
CCCP	20 μM CCCP for 1 to 3 hours			HeLa cells			Positive		247
FCCP	10 μM FCCP for 48 to 72 hours			HeLa cells			Positive		247
Ultraviolet B	100 mJ/cm2		human	Normal epidermal keratinocytes			Positive		247
Ultraviolet C	60 mJ/cm2		Mouse	embryonic fibroblasts			Positive		247
Wortmannin	100 nM			SH-SY5Y neuroblastoma cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.		Positive		252
hydroxychloroquine	30 μM			SH-SY5Y neuroblastoma cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.		Positive		252
Troglitazone	10 µM		Wistar rat	Isolated rat liver mitochondria	Measurement of MPT using vesicle-fused mitochondria ( isolated mitochondria were preincubated with micellized phospholipid containing CL or CLOOH,and then a swelling assay was performed. )	increase	Positive		225
Troglitazone	25 µM			HepG2 cells	Images from transmission electron microscopy	abnormal	Positive		332
Troglitazone	25 µM			HepG2 cells	confocal laser scanning microscopy (MitoTracker Red)		Positive		332
3-methyladenine	10 mM			SH-SY5Y neuroblastoma cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.		Positive		252
Bafilomycin A1	50 nM			SH-SY5Y neuroblastoma cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.		Positive		252
CCCP	10 μM or 25 μM			mouse embryonic fibroblasts (MEFs) and SH-SY5Y cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.		Positive		252
earle’s balanced salt solution							Positive		252
rapamycin			mouse	embryonic retinas	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye		Positive		252
Cyclosporin A	5 μM			mouse embryonic fibroblasts (MEFs) and SH-SY5Y cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye	block	Positive		252
Nicotinamide	5 mM	6h		SH-SY5Y cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.	induce	Positive		252
fisetin	10 μM	6h		SH-SY5Y cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.	induce	Positive		252
Dyclonine			mouse	neuron	Mitochondrial morphology and neurite area measurements	induce	Positive		269
Benoxinate			mouse	neuron	Mitochondrial morphology and neurite area measurements	induce	Positive		269
Phenyl aminosalicylate			mouse	neuron	Mitochondrial morphology and neurite area measurements	induce	Positive		269
genistein			mouse	neuron	Mitochondrial morphology and neurite area measurements	induce	Positive		269
Celecoxib			mouse	neuron	Mitochondrial morphology and neurite area measurements	induce	Positive		269
Yohimbine			mouse	neuron	Mitochondrial morphology and neurite area measurements	induce	Positive		269
penfluridol			mouse	neuron	Mitochondrial morphology and neurite area measurements	induce	Positive		269
pimozide			mouse	neuron	Mitochondrial morphology and neurite area measurements	induce	Positive		269
Doxepin			mouse	neuron	Mitochondrial morphology and neurite area measurements	induce	Positive		269
quercetin				HepG			Positive		263
quercetin				brain			Positive		265
piceatannol		48hr		Mfn1−/− MEFs stably expressing an Mfn1 promoter reporter construct	Relative luciferase activity was determined in Mfn1−/− MEFs carrying the Mfn1 promoter reporter		Positive		276
Nimesulide	10 μM	20 minutes	rat; Wistar; normal	liver mitochondria	Measurements of mitochondrial swelling	increase	Positive	ID50	12
Nimesulide	7.3 μM	20 minutes	rat; Wistar; arthritis	liver mitochondria	Measurements of mitochondrial swelling	increase	Positive	ID50	12
tacrolimus				beta cells from isolated rat islets	Transmission electron microscopy and 3D reconstruction of mitochondria	decrease	Positive		322
Xanthohumol	30μM	24hr		MCF7 cells	using the MAP1LC3II/I ratio to monitor the autophagic flux; quantifiedPMPCB staining	block	Positive		283
doxycycline	15 µg/ml	6 days		143B osteosarcoma cells	BN PAGE analysis, In-gel complex I activity and western blotting	inhibitor	Positive		285
Chloramphenicol	50 μg/ml	5 days		143B osteosarcoma cells	Blue Native Gel	inhibitor	Positive		286
Chloramphenicol	50µg/mL	4 days			complex I de novo assembly analysed by BN-PAGE	inhibitor	Positive		287
MG-132	20 μM	6 hr		HeLa cells	The cells were stained with MitoTracker Green FM and MitoSOX Red dyes followed by image acquisition on a confocal microscope.	induce	Positive		291
Hydrazine	2 mM	22-24 h		primary culture rat hepatocytes, RL-34(JCRB 0247), COS-1(JCRB 9082) IAR-20(JCRB 0610)		induce	Positive		292
H2O2	0.2mM	22hr		rimary culture rat hepatocytes, RL-34,COS-1, IAR-20		induce	Positive		292
Chloramphenicol	200-300µg/ml	22hr		primary culture rat hepatocytes, RL-34,COS-1, IAR-20		induce	Positive		292
Ethidium Bromide	200-300 µg/ml, 2	22h		RL-34, COS-1, IAR-20L cells (mouse fibrob-lasts)		induce	Positive		292
Erythromycin	200 µg/ml	22 h		primary culture rat hepatocytes, RL-34,COS-1, IAR-20		induce	Positive		292
Indomethacin	0.3-0.5 mM	22 h		primary culture rat hep-atocytes, RL-34,COS-1, IAR-20		induce	Positive		292
Ethanol	12.5-500 mM	5min	rat	cardiac myocytes		induce	Positive		292
Ethanol	1-3%	6hr		RL-34		induce	Positive		292
Niclosamide	1, 5, and 10 uM	3 hr (1.5-6hr)		HeLa/mito-YFP	fluorescence microscope	induce	Positive		294
Diazepam	140μg/ml	16hr		PE cells	Energy-dependent accumulation of ethylrhodamine ; Electron micrographs of ultrathin sections	induce	Positive		293
Teriflunomide						induce	Positive		295
Leflunomide	50 μM	48 hr		HeLa cells, C2C12 muscle cells, MEF cells	Mfn2 and Mfn1 mRNA levels; MFN2, MFN1, and porin protein levels; images of mitochondrial morphology ;	induce	Positive		295
brequinar sodium	1 μM	48hr		C2C12 cells		induce	Positive		295
BGP-15	50 μM	4hr		WRL-68 cells	Polyethylene glycol (PEG) fusion assay; OPA1 GTPase assay and OPA1-OPA1 interactions	induce	Positive		297
BGP-15	50 μM	4hr		WRL-68 cells	mERFP-labeled WRL-68 cells	reduce	Positive		297
H2O2	10 μmol/10E7 cells	4-6hr	C2C12 mouse	muscle myoblasts	detected by either MitoTracker Red staining, or by mERFP transfection	induce	Positive		297

F0301. mass
F0302. size
F0303. swelling
F0304. localization
F0305. length
F0306. shape
F0307. ultrastructure
F0308. mitochondrial dynamics
F0309. ER-mitochondria tethering
F0310. protein-containing complex assembly
F0311. cellular component assembly
F030501. elongation
F030601. volume
F030602. formation and maintenance of cristae structure
F030603. fragmentation
F030604. megamitochondria
F030701. tubulization
F030702. structure integrity
F030801. mitophagy
F030802. biogenesis
F030803. fusion
F030804. fission
F031001. mitochondrial respiratory chain complex assembly
F031101. iron-sulfur cluster assembly

T118. Peptidyl-prolyl cis-trans isomerase F, mitochondrial
T251. Dihydroorotate dehydrogenase
T260. Prohibitin-2
T358. Dynamin-1-like protein
T363. Dynamin-like 120 kDa protein, mitochondrial
T416. Serine/threonine-protein kinase mTOR
T419. Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
T489. Mitofusin-1