Compound	Dose	Time	Species	Model	Method	Result	Positive criterion	Reference
Sodium Azide	11			LUHMES (Lund human mesencephalic) cells	Glc–Gal–NeuriTox assay	Positive	EC25(NA) [Glc/Gal]	326
Benoxaprofen	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	Negative	p < 0.05	3
Bezafibrate	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	Negative	p < 0.05	3
Chlorpromazine	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	Negative	p < 0.05	3
Dantrolene	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	Negative	p < 0.05	3
Zidovudine						Positive		307
Acyclovir						Positive		307
Ganciclovir						Positive		307
Zalcitabine						Positive		307
Diclofenac	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	Negative	p < 0.05	3
Fluconazole	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	Negative	p < 0.05	3
Carbon Monoxide						Positive		254
gefitinib	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	Positive	p < 0.05	3
Linezolid	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	Negative	p < 0.05	3
Ciprofloxacin						Positive		307
Metformin	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	Negative	p < 0.05	3
Nefazodone	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	Positive	p < 0.001	3
paroxetine	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	Negative	p < 0.05	3
pravastatin	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	Negative	p < 0.05	3
Primaquine	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	Negative	p < 0.05	3
radicicol	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	Negative	p < 0.05	3
sertraline						Positive		307
Fluoxetine						Positive		307
Rosiglitazone	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	Negative	p < 0.05	3
ethylxanthate						Positive		167
bisulfate						Positive		167
semicarbazide						Positive		167
Simvastatin	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	Positive	p < 0.001	3
salicyaldoxime						Positive		167
Tamoxifen	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	Positive	p < 0.001	3
trazodone	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	Negative	p < 0.05	3
Acetylsalicylic acid						Positive		35
Trovafloxacin	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	Negative	p < 0.05	3
Peroxynitrite	2mM		rat	heart mitochondria	oxidation of reduced cytochrome c oxidase at 550nm	Negative		298
Tamoxifen	8.1 μM		bovine	heart mitochondria	Measurement of complex V activity	Positive	IC50	3
Tamoxifen						Positive		35
Amiodarone	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	Positive	p < 0.05	3

T005001. Cytochrome c oxidase subunit 1
T005002. Cytochrome c oxidase subunit 2
T005003. Cytochrome c oxidase subunit 3
T005004. Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
T005005. Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
T005006. Cytochrome c oxidase subunit 5A, mitochondrial
T005007. Cytochrome c oxidase subunit 6A1, mitochondrial
T005008. Cytochrome c oxidase subunit 6B1
T005009. Cytochrome c oxidase subunit 7B, mitochondrial
T005010. Cytochrome c oxidase subunit 8A, mitochondrial
T005011. Cytochrome c oxidase subunit NDUFA4
T005012. Cytochrome c oxidase assembly factor 5
T005013. Cytochrome c oxidase assembly factor 6 homolog
T005014. Cytochrome c oxidase assembly factor 7
T005015. Cytochrome c oxidase assembly protein COX14
T005016. Cytochrome c oxidase assembly protein COX20, mitochondrial
T005017. Cytochrome c oxidase subunit 5B, mitochondrial
T005018. Cytochrome c oxidase subunit 6A2, mitochondrial
T005019. Cytochrome c oxidase subunit 6C
T005020. Cytochrome c oxidase subunit 7A1, mitochondrial
T005021. Cytochrome c oxidase subunit 7C, mitochondrial

F020103. electron transport chain
F020403. glucose galactose IC50 ratio