F0308 | Mitochondrial dynamics


Organization of mitochondria >> mitochondrial dynamics

Compound Dose Time Species Model Method Action Result Positive criterion Reference
Mdivi-1 inhibitor Positive 296
Mdivi-1 Positive 248
Urolithin A enhance Positive 248
Ozone 1 μg O 3/mL HeLa cells Positive 247
Ozone 10 μg O 3/mL HeLa cells Positive 247
Nicotine 10 mM Human Human embryonal carcinoma cells (NT2/D1) Positive 247
Cisplatin 3 mg/kg bodyweight twice a week for 2 weeks Mouse Mouse tibial nerves and dorsal root ganglia (L1–L4) Positive 247
Doxorubicin 7.2 μM DXR for 24 hrs Human fibroblasts Positive 247
MDMA 20 μM MDMA mixture for 24 hrs Mouse primary hippocampal neurons Positive 247
Metamfetamine 0.5, 1, 2 mM Meth for 24 hrs Human neuroblastoma SH- SY5Y Positive 247
Perfluorooctanoic acid In utero exposure (GD 1–17) to 1 mg/kg bodyweight dam Post-natal day 91 mouse livers Positive 247
Cadmium In vitro: 12uM CdCl2 In vivo: 2mg/kg CdCl2 Rat hepatocytes Positive 247
Manganese Infusion of 1 μM MnCl2 Rat glia Positive 247
Methylmercury 20 μM Human HepG2 cells Positive 247
Chlorpyrifos 30 μM Human stem cell-derived neural progenitor cells Positive 247
2,4-dinitrophenol 50 μM DNP at 3 hours post fertilization (hpf) Danio rerio Positive 247
CCCP 20 μM CCCP for 1 to 3 hours HeLa cells Positive 247
FCCP 10 μM FCCP for 48 to 72 hours HeLa cells Positive 247
Ultraviolet B 100 mJ/cm2 human Normal epidermal keratinocytes Positive 247
Ultraviolet C 60 mJ/cm2 Mouse embryonic fibroblasts Positive 247
XCT790 inhibit Positive 308
Rosiglitazone 1, 2, 4, 7, 24, and 48 hrs Murine differentiated 3T3-L1 and C3H/10T1/2 adipocytes increase Positive 179
Wortmannin 100 nM SH-SY5Y neuroblastoma cells Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye. Positive 252
hydroxychloroquine 30 μM SH-SY5Y neuroblastoma cells Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye. Positive 252
3-methyladenine 10 mM SH-SY5Y neuroblastoma cells Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye. Positive 252
Bafilomycin A1 50 nM SH-SY5Y neuroblastoma cells Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye. Positive 252
CCCP 10 μM or 25 μM mouse embryonic fibroblasts (MEFs) and SH-SY5Y cells Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye. Positive 252
earle’s balanced salt solution Positive 252
rapamycin mouse embryonic retinas Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye Positive 252
Cyclosporin A 5 μM mouse embryonic fibroblasts (MEFs) and SH-SY5Y cells Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye block Positive 252
Nicotinamide 5 mM 6h SH-SY5Y cells Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye. induce Positive 252
fisetin 10 μM 6h SH-SY5Y cells Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye. induce Positive 252
Xanthohumol 30μM 24hr MCF7 cells using the MAP1LC3II/I ratio to monitor the autophagic flux; quantifiedPMPCB staining block Positive 283
sertraline decrease Positive 307
Fluoxetine decrease Positive 307
quercetin HepG Positive 263
quercetin brain Positive 265
colchicine Positive 185
Teriflunomide induce Positive 295
Leflunomide 50 μM 48 hr HeLa cells, C2C12 muscle cells, MEF cells Mfn2 and Mfn1 mRNA levels; MFN2, MFN1, and porin protein levels; images of mitochondrial morphology ; induce Positive 295
Chlorpyrifos 30 μM Human Human induced pluripotent stem cells (iPSCs) increase Positive 242
docetaxel Positive 185
BGP-15 50 μM 4hr WRL-68 cells Polyethylene glycol (PEG) fusion assay; OPA1 GTPase assay and OPA1-OPA1 interactions induce Positive 297
piceatannol 48hr Mfn1−/− MEFs stably expressing an Mfn1 promoter reporter construct Relative luciferase activity was determined in Mfn1−/− MEFs carrying the Mfn1 promoter reporter Positive 276