Compound	Dose	Time	Species	Model	Method	Result	Positive criterion	Reference
Leucinostatin	11 μg/mg protein		C. asciculate	SMP-ATPase		Positive	IC50	131
Leucinostatin	2 μg inhibitor/ml		spinach	chloroplast		Positive	IC50	132
Leucinostatin	0.1-0.4 μg/mg protein		rat	isolated liver mitochondria		Positive		133
efrapeptins	0.56 mol/mol F1		bovine	heart MF1-ATPase		Positive	IC50	134
efrapeptins	70 ng/ml		C. asciculate	MF1-ATPase		Positive	IC50	135
efrapeptins	0.3 μM		human	umbilical vein endothelial cell, nonmitochondrial ATP synthase		Positive	IC50	136
efrapeptins	0.5 μg/ml		R. rubrum	chromatophores		Positive	IC50	137
efrapeptins	0.05-0.5 μg of inhibitor/mg protein		T. pyriformis	SMP-ATPase		Positive	IC50	138
efrapeptins	21.5 μM			EF1-ATPase		Positive	ki	139
efrapeptins	10 nM		bovine	heart MF1-ATPase		Positive	kd	134
efrapeptins	2.4 mol inhibitor/mol enzyme		bovine	heart SMP-ATPase		Positive	complete inhibition	134
resveratrol	27.7 μM		rat	brain SMP, ATP synthesis		Positive		140
resveratrol	14 μM		rat	liver MF1-ATPase		Positive		141
resveratrol	19 μM		rat	brain M F0F1-ATPase		Positive		140
resveratrol	6.4 μM		bovine	bovine heart MF1-ATPase		Positive		142
resveratrol	2 μM		human	human umbilical vein endothelial cell, nonmitochondrial ATP synthase, ATP synthesis		Positive		136
Diethylstilbestrol	10 μM		rat	liver MF0F1-ATPase		Positive		143
Diethylstilbestrol	10-25 μM		rat	brain MF0F1-ATPase		Positive		141
SITS	∼1.3 μM		V. parahaemolyticus	F0F1-ATPase		Positive		144
SITS	25 μM		V. parahaemolyticus	F1-ATPase		Positive	95% inhibition	145
DIDS	20.9 μM		rat	liver MF1ATPase		Positive		146
quercetin	5 kmol/mol		bovine	heart MF1-ATPase		Positive	IC50	147
quercetin	85 μM		bovine	heart MF1-ATPase		Positive	IC50	148
quercetin	180 μM		bovine	heart SMP-ATPase		Positive	IC50	148
quercetin	50 μM		rat	brain F0F1-ATPase		Positive	IC50	140
quercetin	3 μM		rat	liver F1-ATPase		Positive	IC50	141
quercetin	2 kmol/mola		spinach	CF1-ATPase		Positive		147
quercetin	2.6 μg/mg protein		C. asciculate	SMP-ATPase		Positive	IC50	131
quercetin	0.2 mM		pig	heart MF1-ATPase		Positive	Ki	149
quercetin	27 μM		bovine	heart MF1-ATPase		Positive	Kd	147
quercetin	5 μM		C. thermoaceticum	membrane-bound F0F1-ATPase		Positive	46% inhibition	150
kaempferol	55 μM		rat	brain MF0F1-ATPase		Positive	IC50	140
morin	60 μM		rat	brain MF0F1-ATPase		Positive	IC50	140
apigenin	105 μM		rat	brain MF0F1-ATPase		Positive	IC50	140
genistein	55 μM		rat	brain MF0F1-ATPase		Positive	IC50	140
genistein	50 μM		rat	liver F1-ATPase		Positive	10% inhibition	141
Biochanin A	65 μM		rat	brain MF0F1-ATPase		Positive	IC50	140
Daidzein	127 μM		rat	brain MF0F1-ATPase		Positive	IC50	151
Oligomycin	152 μg inhibitor/mg protein		E. coli	membrane vesicle		Positive	IC50	152
Oligomycin	7.1 μg inhibitor/mg protein		C. asciculate	SMP-ATPase		Positive	IC50	131
Oligomycin	2.0-3.0 μg inhibitor/mg protein		S. cerevisiae	SMP-ATPase		Positive	IC50	153
Oligomycin	0.3 μM		human	NCI-60 cell lines, F0F1-ATPase		Positive	IC50	154
Oligomycin	15 ng inhibitor/mg protein		N. crassa	SMP-ATPase		Positive	Ki	155
Oligomycin	0.21 μM		bovine	heart MF0F1-ATPase		Positive	Ki	156
Oligomycin	0.4 μg inhibitor/mg protein		bovine	heart SMP-ATPase		Positive	95% inhibition	157
Oligomycin	0.5 μg/ml		rat	liver SMP-ATPase		Positive	75% inhibition	158
peliomycin	4.5 μg inhibitor/mg protein		S. cerevisiae	SMP-ATPase		Positive	IC50	153
venturicidin B	9 μg inhibitor/mg protein		E. coli	membrane vesicle		Positive	IC50	152
mefloquine						Positive		35
venturicidin B	11 μg inhibitor/mg protein		E. coli	membrane-bound ATPase		Positive	IC50	152
venturicidin B	0.06-0.18 (A and B) and 11.0 (X) μg inhibitor/mg protein		S. cerevisiae	SMP-ATPase		Positive	IC50	159
venturicidin B	5-11 μg inhibitor/mg protein		T. pyriformis			Positive	IC50	138
venturicidin B	0.13 μg inhibitor/mg protein					Positive	IC50	153
venturicidin B	3.0 μg/mg protein		C. asciculate	SMP-ATPase		Positive	IC50	131
venturicidin B	0.5 μM		spinach	thylakoids		Positive	IC50	160
venturicidin B	0.5 μM		spinach	thylakoids, ATPase		Positive	IC50	160
ossamycin	1.3 μg of inhibitor/mg protein		S. cerevisiae	SMP-ATPase		Positive	IC50	153
ossamycin	46 μg of inhibitor/mg protein		E. coli	membrane vesicle		Positive	IC50	152
ossamycin	8 μM		human	NCI-60 cell lines, F0F1-ATPase		Positive	IC50	154
paroxetine						Positive		35
apoptolidin	4-5 μM		S. cerevisiae	membrane-bound F0F1-ATPase		Positive	Ki	161
apoptolidin	18 μM		human	NCI-60 cell lines, F0F1-ATPase		Positive	IC50	154
cytovaricin	1 μM		human	NCI-60 cell lines, F0F1-ATPase		Positive	IC50	154
cytovaricin	0.4 μM		S. cerevisiae	membrane-bound F0F1-ATPase		Positive	Ki	161
ossamycin	0.8 μM			60 human cancer cell lines of the National Cancer Institute		Positive	mean	184
Tamoxifen						Positive		35
Oligomycin						Positive		35
Oligomycin	8.7			LUHMES (Lund human mesencephalic) cells	Glc–Gal–NeuriTox assay	Positive	EC25(NA) [Glc/Gal]	326
Oligomycin	152 μg inhibitor/mg protein		E. coli	membrane vesicle, pH gradient formation		Positive		170
Oligomycin	7.1 μg inhibitor/mg protein		C. asciculate	SMP-ATPase		Positive	IC50	170
Oligomycin	2.0-3.0 μg inhibitor/mg protein		S. cerevisiae	SMP-ATPase		Positive	IC50	170
Oligomycin	0.3 μM		human NCI-60 cell lines	F0F1-ATPase		Positive	IC50	170
Oligomycin	15 ng inhibitor/mg protein		N. crassa	SMP-ATPase		Positive	Ki	170
Oligomycin	0.21 μM		bovine	heart MF0F1-ATPase		Positive	Ki	170
Oligomycin	0.4 μg inhibitor/mg protein		bovine	heart SMP-ATPase		Positive	95% inhibition	170
Oligomycin	0.5 μg/ml		rat	liver SMP-ATPase		Positive	75% inhibition	170
ossamycin	46 μg of inhibitor/mg protein		E. coli	pH gradient formation by membrane vesicle		Positive	IC50	170
ossamycin	8 μM		human NCI-60 cell lines	F0F1-ATPase		Positive	IC50	170
ossamycin	1.3 μg of inhibitor/mg protein		S. cerevisiae	SMP-ATPase		Positive	IC50	170
venturicidin B						Positive		170
Bedaquiline						Positive		170
tributyltin chloride	200 nM		E. coli and	F0F1-ATPase		Positive		170
tributyltin chloride	200 nM		I. tartaricus	F0F1-ATPase		Positive		170
tributyltin chloride	1 μM		C. thermoaceticum	membrane-bound F0F1-ATPase		Positive	47% inhibition	170
tributyltin chloride	5 μM		C. thermoaceticum	membrane-bound F0F1-ATPase		Positive	87% inhibition	170
tributyltin chloride	1 μM			TF0F1-ATPase		Positive	80% inhibition	170
NCCD	0.65 nmol/mg protein		bovine	heart SMP-ATPase		Positive	IC50	170
NCCD	1 nmol NCCD/mg protein		bovine	heart SMP-ATPase		Positive	85% inhibition	170
substrate analogs						Positive		170
tentoxin	∼0.6 mol/mol		spinach	CF1-ATPase		Positive	IC50	170
tentoxin	50 nM		spinach	CF1(-ɛ)-ATPase		Positive	IC50	170
tentoxin	0.4-0.6 μM		lettuce	chloroplasts, photophosphorylation		Positive	IC50	170
tentoxin	10 nM		spinach	CF1(-ɛ)-ATPase		Positive	Ki	170
tentoxin	30-60 μM			TF1-ATPase		Positive	Ki	170
tentoxin	8-10 nM		spinach	CF1(-ɛ)-ATPase		Positive	Kd	170
efrapeptins						Positive		170
azide						Positive		170
resveratrol						Positive		170
N,N'-dicyclohexylcarbodiimide	0.2 μg of inhibitor/mg protein		S. cerevisiae	SMP-ATPase		Positive	IC50	170
N,N'-dicyclohexylcarbodiimide	1-5 μg of inhibitor/mg protein		T. pyriformis	SMP-ATPase		Positive	IC50	170
N,N'-dicyclohexylcarbodiimide	200 μMa in less than 5 min and at ∼40 μMa in 30 min		R. rubrum	F1-ATPase		Positive		170
N,N'-dicyclohexylcarbodiimide	1.9 μg/mg protein		C. fasciculata	SMP-ATPase		Positive	IC50	170
Oligomycin	8 nM		bovine	heart mitochondria	Measurement of complex V activity	Positive	IC50	3
aurovertin B	1.5 μM		bovine	heart mitochondria	Measurement of complex V activity	Positive	IC50	3
N,N'-dicyclohexylcarbodiimide	1 mol DCCD/mol F1			EF1-ATPase		Positive	95% inhibition	170
N,N'-dicyclohexylcarbodiimide	30 μM			membrane-bound EF0F1-ATPase		Positive	maximal 70-80% inhibition	170
N,N'-dicyclohexylcarbodiimide	5 μM		C. thermoaceticum	membrane-bound F0F1-ATPase		Positive	47% inhibition	170
N,N'-dicyclohexylcarbodiimide	2 mol inhibitor bound/mol F1		bovine	heart MF1-ATPase		Positive	97% inhibition	170
Amiodarone	50 μM		bovine	heart mitochondria	Measurement of complex V activity	Positive	p < 0.001	3
N,N'-dicyclohexylcarbodiimide	1 mol inhibitor/mol F0		bovine	heart SMP-ATPase		Positive	maximal inhibition	170
N,N'-dicyclohexylcarbodiimide	2 mol inhibitor/mol F0		bovine	heart H+-translocation		Positive	maximal inhibition	170
N,N'-dicyclohexylcarbodiimide	1 mol inhibitor/mol F0		E. coli	membrane H+-translocation		Positive	maximal inhibition	170
woodward's reagent k						Positive		170
Benoxaprofen	50 μM		bovine	heart mitochondria	Measurement of complex V activity	Negative	p < 0.05	3
N,N'-dicyclohexylcarbodiimide						Positive		170
woodward's reagent k						Positive		170
Bezafibrate	50 μM		bovine	heart mitochondria	Measurement of complex V activity	Negative	p < 0.05	3
Enterostatin						Positive		170
ethyldimethylaminopropyl carbodiimide	13 mol of EDC/mol F1 (EF1-ATPase)					Positive	95% inhibition	170
1,5-difluoro-2,4-dinitrobenzene						Positive		170
Chlorpromazine	50 μM		bovine	heart mitochondria	Measurement of complex V activity	Positive	p < 0.001	3
NBD-Cl						Positive		170
NBD-Cl						Positive		170
Mersalyl	130 μM		bovine	heart MF0, proton conductivity		Positive	70% inhibition	170
Dantrolene	50 μM		bovine	heart mitochondria	Measurement of complex V activity	Negative	p < 0.05	3
Diclofenac	50 μM		bovine	heart mitochondria	Measurement of complex V activity	Positive	p < 0.01	3
cyclophilin D						Positive		171
Fluconazole	50 μM		bovine	heart mitochondria	Measurement of complex V activity	Negative	p < 0.05	3
gefitinib	50 μM		bovine	heart mitochondria	Measurement of complex V activity	Positive	p < 0.001	3
Linezolid	50 μM		bovine	heart mitochondria	Measurement of complex V activity	Negative	p < 0.05	3
Metformin	50 μM		bovine	heart mitochondria	Measurement of complex V activity	Negative	p < 0.05	3
Nefazodone	50 μM		bovine	heart mitochondria	Measurement of complex V activity	Positive	p < 0.001	3
paroxetine	50 μM		bovine	heart mitochondria	Measurement of complex V activity	Positive	p < 0.001	3
pravastatin	50 μM		bovine	heart mitochondria	Measurement of complex V activity	Negative	p < 0.05	3
Primaquine	50 μM		bovine	heart mitochondria	Measurement of complex V activity	Negative	p < 0.05	3
radicicol	50 μM		bovine	heart mitochondria	Measurement of complex V activity	Negative	p < 0.05	3
Rosiglitazone	50 μM		bovine	heart mitochondria	Measurement of complex V activity	Negative	p < 0.05	3
Simvastatin	50 μM		bovine	heart mitochondria	Measurement of complex V activity	Positive	p < 0.001	3
Tamoxifen	50 μM		bovine	heart mitochondria	Measurement of complex V activity	Positive	p < 0.001	3
Diazepam	140μg/ml			PE cells	potentiometric method	Positive	inhibit 60%	293
trazodone	50 μM		bovine	heart mitochondria	Measurement of complex V activity	Negative	p < 0.05	3
Trovafloxacin	50 μM		bovine	heart mitochondria	Measurement of complex V activity	Negative	p < 0.05	3
Peroxynitrite	2mM, IC50=0.63mM		rat	heart mitochondria	ATPase activity was assayed by coupling to the reactions of pyruvate kinase with lactace dehydrogenase following NADH oxidation at 340nm	Positive	IC50	298
Tamoxifen	1.6 μM		bovine	heart mitochondria	Measurement of complex V activity	Positive	IC50	3
Tamoxifen	29 μM		bovine	heart mitochondria	Measurement of complex V activity	Positive	IC50	3
Tamoxifen	26 μM		bovine	heart mitochondria	Measurement of complex V activity	Positive	IC50	3

T019001. c ring
T019002. Fo subunits
T019003. F1 subunits
T019004. ATP synthase subunit O, mitochondrial
T019005. ATP synthase subunit g, mitochondrial
T019006. ATP synthase subunit e, mitochondrial
T019007. ATP synthase subunit epsilon, mitochondrial
T019008. ATP synthase mitochondrial F1 complex assembly factor 2
T019009. Transmembrane protein 70, mitochondrial
T019010. ATP synthase membrane subunit DAPIT, mitochondrial
T019011. ATP synthase subunit a
T019012. ATP synthase protein 8
T019013. V-type proton ATPase catalytic subunit A
T019002001. ATP synthase F(0) complex subunit C1, mitochondrial
T019003001. ATP synthase subunit gamma, mitochondrial
T019003002. ATP synthase subunit delta, mitochondrial
T019003003. ATP synthase subunit alpha, mitochondrial
T019003004. ATP synthase subunit beta, mitochondrial

F0110. proton conductivity
F020103. electron transport chain
F020403. glucose galactose IC50 ratio
F021201. ATP synthesis
F021204. ATP hydrolysis